556801-41-3

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 556801-40-2 1-(2-fluoro-4 nitrophenyl)-4-phenylpiperazine 
• 501-53-1 benzyl chloroformate 
• 478079-57-1 3-fluoro-4-(4-phenylpiperazin-1-yl)aniline 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 465520-07-4 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol 
• 735276-50-3 (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]amine 
• 465520-11-0 (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 556801-42-4 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 
• 556801-43-5 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide 

Relevant academic research and scientific papers

Preparation method of oxazolidinone compound

The invention provides a preparation method of an oxazolidinone compound, particularly relates to a novel preparation method of (S)-[N-3-(3-fluorine-4-(4-phenyl piperazinyl) phenyl)-2-oxo-5-oxazolidinyl] methylacetamide, and relates to the medical field. According to the existing preparation method, the reagent selection effect is non ideal, so that the existing preparation method is high in post-treatment operation difficulty, low in yield and unfavorable for industrial expansion. All the steps are improved; use of raw materials with relatively high toxicity is avoided, and better reagents and a treatment process which is easier to operate are selected; the product yield is greatly increased; the process is more stable and favorable for industrial production.

A method for the prevention or treatment of mycobacterial diseases

Disclosed in the present invention is a drug for preventing or treating mycobacterial diseases. In particular, disclosed is the use of a compound represented by the following general formula (I) or pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs thereof in preparing drugs for preventing or treating mycobacterial diseases, providing a new way for the prevention and treatment of tuberculosis and the like.

CERTAIN CRYSTALLINE HYDRATES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR PREPARATION AND USE THEREOF

At least one crystalline hydrate of (S)-[N-3-(3'-fluoro-4'-(4''-phenyl piperazinyl)) phenyl-2-oxo-5-oxazolidinyl] methyl acetamide, such as those with the following formula, wherein y is a number ranging from 1/12 to 1. Also provided are methods for the preparation of such crystalline hydrates, pharmaceutical compositions comprising such crystalline hydrates, and methods for their uses.

Synthesis and antibacterial activity of linezolid analogues

Several new compounds of oxazolidinone class were designed and synthesized referring to the structure-activity relationship studies and the synthesis of Linezolid, and their antibacterial activity was studied.