55682-30-9

Upstream product

• 109541-24-4 1,2-Diphenyl-2-[(Z)-piperidin-1-ylimino]-ethanone 
• 6940-78-9 4-chlorobutyl bromide 
• 668-94-0 4,5-diphenyl-1H-imidazole 
• 2818-82-8 2-methyl-4,5-diphenyl-1H-imidazole 
• 109-70-6 1.3-chlorobromopropane 
• 14224-99-8 2-methyl-4,5-diphenyloxazole 
• 91621-01-1 2-(2-oxopropyl)-4,5-diphenyloxazole 
• 134-81-6 benzil 

Relevant academic research and scientific papers

Synthesis of annelated imidazoles and benzimidazoles

A variety of fused ring imidazole or benzimidazole derivatives were prepared through two successive condensations of a dihalide with 4,5- diphenylimidazole or benzimidazole. The 2-methyl substituted derivatives of 4,5-diphenylimidazole or benzimidazole were also used. The size of the annelated ring, which is dependent on the dihalide used, can be varied from five to seven atoms. Initially, N-alkylhalo derivatives were prepared by condensation of the heterocyclic starting materials with a dihalide. Ring closure was then effected through intramolecular condensation of a carbanion derived from the 2-position or the 2-methyl group of the parent heterocyclic ring with the N-alkylhalo moiety.

4,5-DIPHENYLIMIDAZOLES FROM THE CYCLIZATION OF BENZIL N-ALKYLMONOHYDRAZONES

The thermal cyclization of monodisubstituted hydrazones (1) affords the corresponding N-substituted-4,5-diphenylimidazoles in good to excellent yields; possible mechanisms for this unusual cyclization are presented.

Synthesis of 1,2-Polymethyleneimidazoles Utilizing Intramolecular Ring Transformation

Among the intramolecular cyclodehydration of 2-(β-, δ-, and ε-aminoalkyl)oxazoles, 2-(δ-aminoalkyl)oxazoles afforded the desired 1,2-tetramethyleneimidazoles on pyrolysis, while 2-(β- and ε-aminoalkyl)oxazoles unchanged under the same conditions.