55728-65-9

Upstream product

• 35002-94-9 thymidine 3'-[thymidine 5'-(methyl phosphate)] 
• 4850-55-9 2,2,2-trimethoxy-4,5-diphenyl-2,2-dihydro-1,3,2-dioxaphospholene 
• 50-89-5 thymidine 
• 90362-21-3 thymidylyl-(3'-(methyl)5')-thymidylyl-(3'-(methyl)5')-thymidine 
• 90362-22-4 thymidylyl-(3'-(methyl)5')-thymidylyl-(3'-(methyl)5')-thymidylyl-(3'-(methyl)5')-thymidine 
• 67-56-1 methanol 
• 365-07-1 thymidine 5'-phosphate 
• 512-56-1 trimethyl phosphite 

Relevant academic research and scientific papers

Ester exchange reaction of oxyphosphorane with thymidine

Ester exchange reaction of oxyphosphorane (1) with thymidine (2) afforded diastereomeric spirooxyphosphoranes 3 under mild conditions in good yield. After hydrolysis, thymidine phosphates monomers (5,6) and dimer (7) were obtained.

METHYLATION OF DEOXYNUCLEOTIDES WITH TRIMETHYL PHOSPHATE IN AQUEOUS PHASE.

Action of trimethyl phosphate on thymidine 5 prime -phosphate, deoxycytidine 5 prime -phosphate, deoxyadenosine 5 prime -phosphate, and deoxyguanosine 5 prime -phosphate at 37-60 degree C, and pH 7-10 gave their methyl esters and base-methylated derivatives. Esterification took place in all deoxyribonucleotides to the almost same extent and its rate was enhanced by the reaction temperature, while being independent of pH in the range 7-10. On the other hand, methylation of the base moieties was affected by both the reaction temperature and pH of the reaction medium.