55740-90-4Relevant academic research and scientific papers
Branched-selective intermolecular ketone α-alkylation with unactivated alkenes via an enamide directing strategy
Xing, Dong,Dong, Guangbin
, p. 13664 - 13667 (2017)
We describe a strategy for intermolecular branched-selective α-alkylation of ketones using simple alkenes as the alkylating agents. Enamides derived from isoindolin-1-one provide an excellent directing template for catalytic activation of ketone α-positions. High branched selectivity is obtained for both aliphatic and aromatic alkenes using a cationic iridium catalyst. Preliminary mechanistic study favors an Ir-C migratory insertion pathway.
Chemoselective debenzylation involving removal of a 2-hydroxy-1- phenylethyl group from nitrogen
Fains, Olivier,Vernon, John M.
, p. 8265 - 8266 (2007/10/03)
In 2-(2-hydroxy-1-phenylethyl)-1-isoindolinone, selective removal of the 2-hydroxy-1-phenylethyl group is conveniently achieved via a 3-step sequence (mesylation, elimination, hydrolysis) without breaking an endocyclic benzylic nitrogen bond.
