557788-41-7

Upstream product

• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 254744-20-2 4'-hydroxymethyl-2'-methoxymethyl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide 
• 254744-19-9 4'-formyl-2'-methoxymethyl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide 
• 254744-17-7 4-bromo-3-methoxymethyl-benzonitrile 
• 190197-86-5 4-bromo-3-(bromomethyl)benzonitrile 
• 254744-18-8 4-bromo-3-methoxymethyl-benzaldehyde 
• 176961-13-0 2-borono-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide 
• 153624-30-7 2-bromo-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]benzenesulfonamide 
• 153623-86-0 N-(3,4-Dimethyl-5-isoxazolyl)-2-bromo-benzenesulfonamide 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 41963-20-6 4-bromo-3-methylbenzonirtile 
• 254744-21-3 4'-bromomethyl-2'-methoxymethyl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide 

Downstream Products

• 557788-40-6 3-[2'-(3,4-dimethyl-isoxazol-5-ylsulfamoyl)-2-methoxymethyl-biphenyl-4-ylmethyl]-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.

A series of 4'-[(imidazol-1-yl)methyl]biphenylsulfonamides has potent antagonist activity against both angiotensin II AT(1) and endothelin ET(A) receptors. Such dual-acting antagonists could have utility in the treatment of hypertension, heart failure, an