5579-03-3Relevant academic research and scientific papers
A new homologous series of anticonvulsants: Phenyl alcohol amides. Synthesis and pharmacological evaluation
Mezo-Toledo,Zenteno-Garcia,Juarez-Carvajal,Martinez-Munoz,Carvajal-Sandoval
, p. 1289 - 1291 (2007/10/02)
The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (±)-2-Hydroxy-2-phenylbutyramide (1), (±)-3-hydroxy-3-phenylpentanamide (2) and (±)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.
