55790-17-5

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate is used as a reagent for the preparation of nitroethylpyrrolidone compounds, which are important in the development of pharmaceuticals with potential therapeutic applications.
Used in Chemical Synthesis:
In the chemical industry, Methyl 2-oxo-4-phenylpyrrolidine-3-carboxylate is utilized as a building block for the synthesis of various chemical products, including specialty chemicals and intermediates for further reactions. Its unique structure allows for the creation of a wide range of compounds with diverse applications.

Upstream product

• 55790-16-4 (2-nitro-1-phenyl-ethyl)-malonic acid dimethyl ester 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 100-52-7 benzaldehyde 

Downstream Products

• 77519-55-2 2-oxo-4-phenylpyrrolidine-3-carboxylic acid 
• 1341160-75-5 3-methoxycarbonyl-3-[2-nitro-1-(3-pyridyl)ethyl]-4-phenyl-2-pyrrolidone 
• 1005085-89-1 3-methoxycarbonyl-3-[2-nitro-1-(2-furyl)ethyl]-4-phenyl-2-pyrrolidone 
• 1341160-88-0 3-methoxycarbonyl-3-[1-(2-methylindol-3-yl)-2-nitroethyl]-4-phenyl-2-pyrrolidone 
• 1341160-89-1 3-[1-(1,2-dimethylindol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-92-6 3-[1-(1-benzyl-2-methylindol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-82-4 3-methoxycarbonyl-3-[1-(1-methylindol-3-yl)-2-nitroethyl]-4-phenyl-2-pyrrolidone 
• 1341160-86-8 3-[1-(1-benzylindol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1217737-83-1 3-methoxycarbonyl-3-(2-nitro-1-phenylethyl)-4-phenyl-2-pyrrolidone 
• 1341160-73-3 3-methoxycarbonyl-3-[2-nitro-1-(4-chlorophenyl)-ethyl]-4-phenyl-2-pyrrolidone 
• 1341160-70-0 3-[1-(4-N,N-dimethylaminophenyl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 
• 1341160-80-2 3-methoxycarbonyl-3-[1-(1-methylbenzimidazol-2-yl)-2-nitroethyl]-4-phenyl-2-pyrrolidone 
• 1341160-81-3 3-[1-(indol-3-yl)-2-nitroethyl]-3-methoxycarbonyl-4-phenyl-2-pyrrolidone 

Relevant academic research and scientific papers

Efficient synthesis of β-aryl-γ-lactams and their resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.

Process for producing β-phenyl-γ-amino butyric acid hydrochloride

The invention relates to a new substance, namely the hydrochloride of β-phenyl- γ-aminobutyric acid of the following formula: EQU1 and to the process for its production which comprises condensing malonic ester with β-nitrostyrene resulting in the separation of an ester of γ-carbomethoxy-β-phenyl-γ-nitrobutyric acid at a temperature ranging from 0° to 14°C, reducing the ester thus obtained with hydrogen in the presence of the Raney nickel under a pressure of 6 to 30 atm, treating 3-carbomethoxy-4-phenyl-2-pyrrolidone, as formed by the reduction, with hydrochloric acid, and separating the desired product.