55791-98-5

Upstream product

• 612-35-1 2-Benzylbenzoic acid 
• 75-64-9 tert-butylamine 
• 98-80-6 phenylboronic acid 
• 5398-11-8 3-phenylphthalide 
• 15496-40-9 α-hydroxy-N-methyl-α-phenyl-o-toluamide 
• 55810-66-7 2-(benzyl)benzoyl chloride 

Downstream Products

• 55791-99-6 N-tert-butyl-α-phenyl-α-pivaloyl-o-toluamide 
• 55792-00-2 3-tert.butyl-4-phenyl isocarbostyril 
• 55792-01-3 3-tert-butyl-1-chloro-4-phenyl isoquinoline 
• 3532-74-9 2-tert-butyl-3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

Copper-Catalyzed Arylation of Remote C(sp3)?H Bonds in Carboxamides and Sulfonamides

Reported herein is an unprecedented copper-catalyzed arylation of remote C(sp3)?H bonds. Stirring a trifluorotoluene solution of either N-fluorocarboxamides or N-fluorosulfonamides and arylboronic acids in the presence of a catalytic amount of copper(II) trifluoroacetylacetonate, 2,2′-bipyridine, and sodium tert-butoxide afforded the γ- and δ-C(sp3)?H arylated carboxamides and sulfonamides, respectively, in good to high yields. Mechanistic studies indicate that the reaction might proceed through an amidyl radical generation, 1,5-hydrogen atom transfer (HAT), and copper-catalyzed cross-coupling of the resulting carbon radical with arylboronic acids.

N-Heterocyclic-Carbene-Catalyzed C–H Acylation via Radical Relay

A method of N-fluorocarboxamide-directed N-heterocyclic-carbene (NHC)-catalyzed benzylic C–H acylation with aldehydes via the hydrogen atom transfer strategy is disclosed. This transformation involves a sequence of single-electron transfer, 1,5-hydrogen a

3-Substituted-4-aryl isoquinolines

3-Substituted-4-aryl isoquinolines, e.g. 3-tertiary butyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, prepared from corresponding isoquinoline intermediates, are useful as anti-diabetic agents.