55805-03-3

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(1,1-Difluoroethyl)-4-fluorobenzene is utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides to improve human and environmental health.
Used in the Production of Polycarbonate Resins:
As a solvent, 1-(1,1-Difluoroethyl)-4-fluorobenzene plays a crucial role in the production of polycarbonate resins. These resins are widely used in the manufacturing of CDs, DVDs, eyeglass lenses, and other plastic products due to their durability and transparency.
Used in Organic Chemical Reactions:
1-(1,1-Difluoroethyl)-4-fluorobenzene also functions as a reagent in organic chemical reactions, facilitating the synthesis of various organic compounds for different applications, including specialty chemicals and materials.
Used in Electronic Materials and Optical Brightening Agents:
1-(1,1-Difluoroethyl)-4-fluorobenzene finds applications in the production of electronic materials and optical brightening agents, enhancing the performance and efficiency of electronic devices and improving the appearance of fabrics and papers.
Safety Precautions:
It is essential to handle 1-(1,1-Difluoroethyl)-4-fluorobenzene with care, as high-level exposure can lead to skin, eye, and respiratory irritation. Proper safety measures should be taken to minimize the risk of adverse health effects.

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 420-43-9 1-bromo-1,1-difluoroethane 
• 352-13-6 4-flourophenylmagnesium bromide 
• 139214-50-9 2-(4-fluorophenyl)-2-methyl-1,3-dithiane 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 459-47-2 1-ethyl-4-fluorobenzene 

Relevant academic research and scientific papers

METHOD FOR PRODUCING (FLUOROALKYL) ARENE

PROBLEM TO BE SOLVED: To provide a method for efficiently producing fluoroalkyl arene, which is important as synthetic raw materials for medicines and functional materials. SOLUTION: A fluoroalkyl arene is produced by the reaction between an aryl metal species represented by formula (2) and a fluoroalkyl halide represented by formula (3) in the presence of a cobalt compound and an ethylenediamine derivative. In the formula (2) shown in the following figure, R11-R15 independently represent H, a C1-C4 alkyl group or the like. In the formula (3): Y-Rf, Y is Cl or the like; Rf is a C2-C3 fluoroalkyl group. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Cobalt/diamine-catalyzed 1,1-difluoroethylation and 2,2,2-trifluoroethylation of aryl Grignard reagents with corresponding fluoroalkyl halides

Cobalt/diamine-catalyzed 1,1-difluoroethylation and 2,2,2-trifluoroethylation of aryl Grignard reagents with 1,1-difluoroethyl and 2,2,2-trifluoroethyl halides were investigated. With regard to the 1,1-difluoroethylation, 1,2-bis(dimethylamino)-2-methylpropane, which has been rarely used in the cross-coupling reactions, gave the highest yield among the diamine ligands tested. In the 2,2,2-trifluoroethylation, trans-1,2-bis(dimethylamino)cyclohexane provided the desired products in satisfactory yields with not only 2,2,2-trifluoroethyl iodide but also chloride. This Co/diamine catalyst was also effective for the coupling with other partially fluorinated alkyl halides in the presence of appropriate diamine ligands.

(Re)Investigation of the reactivity of uranium hexafluoride toward several organic functions at room temperature

The annual worldwide production of UF6 is very large and this compound is not used. Consequently, it could be interesting to find some applications as organic reagent. UF6 could be considered as an oxidizer of various functions. However, it seems also present some possibilities as a fluorinating reagent in mild conditions.

Designer HF-Based fluorination reagent: Highly regioselective synthesis of fluoroalkenes and gem -difluoromethylene compounds from alkynes

Hydrogen fluoride (HF) and selected nonbasic and weakly coordinating (toward cationic metal) hydrogen-bond acceptors (e.g., DMPU) can form stable complexes through hydrogen bonding. The DMPU/HF complex is a new nucleophilic fluorination reagent that has high acidity and is compatible with cationic metal catalysts. The gold-catalyzed mono- and dihydrofluorination of alkynes using the DMPU/HF complex yields synthetically important fluoroalkenes and gem-difluoromethlylene compounds regioselectively.

Visible light-promoted metal-free C-H activation: Diarylketone-catalyzed selective benzylic mono- and difluorination

We report herein an operationally simple method for the direct conversion of benzylic C-H groups to C-F. We show that visible light can activate diarylketones to abstract a benzylic hydrogen atom selectively. Adding a fluorine radical donor yields the benzylic fluoride and regenerates the catalyst. The selective formation of mono- and difluorination products can be achieved by catalyst control. 9-Fluorenone catalyzes benzylic C-H monofluorination, while xanthone catalyzes benzylic C-H difluorination. The scope and efficiency of this new C-H fluorination method are significantly better than those of the existing methods. This is also the first report of selective C-H gem-difluorination.