55805-12-4Relevant academic research and scientific papers
Pd-Catalyzed Transfer of Difluorocarbene for Three Component Cross-Coupling?
Xu, Zhi-Wei,Zhang, Wei,Lin, Jin-Hong,Jin, Chuan-Ming,Xiao, Ji-Chang
, p. 1647 - 1650 (2020)
Outstanding accomplishments have been achieved in the chemistry of difluorocarbene, but transition- metal-catalyzed transfer of difluorocarbene for coupling remains a challenging task. Herein, we describe a Pd-catalyzed coupling of difluorocarbene with two aryl carbon centers to give difluoromethylenation products, which cannot be obtained by any previous difluorocarbene-transformation method.
DIFLUOROMETHYL AND DIFLUOROMETHYLENE TRANSFER REAGENTS
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Paragraph 0022; 0096, (2020/01/22)
Disclosed herein are borazine, borate, and azaborinine compounds and compositions, methods of making said compounds and compositions, and methods of forming aromatic difluorocarbon compounds and difluorocarbon compounds.
The Difluoromethyl Group as a Masked Nucleophile: A Lewis Acid/Base Approach
Geri, Jacob B.,Wade Wolfe, Michael M.,Szymczak, Nathaniel K.
, p. 9404 - 9408 (2018/08/09)
The difluoromethyl group (R-CF2H) imparts desirable pharmacokinetic properties to drug molecules and is commonly targeted as a terminal functional group that is not amenable to further modification. Deprotonation of widely available Ar-CF2
