55846-70-3

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 823-76-7 Cyclohexyl methyl ketone 
• 62783-63-5 cyclohexyl-oxo-acetic acid methyl ester 
• 70-11-1 α-bromoacetophenone 
• 16616-46-9 1-cyclohexyl-3-phenylprop-2-yn-1-one 
• 98-89-5 Cyclohexanecarboxylic acid 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 60718-45-8 1-cyclohexanecarbonyl-1H-imidazole 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 

Downstream Products

• 1067908-41-1 1-(1-(pent-4-enyl)cyclohexyl)-3-phenylpropane-1,3-dione 
• 106471-19-6 1-cyclohexyl-2-methyl-3-phenylpropane-1,3-dione 
• 304648-30-4 4-(3-Cyclohexyl-5-phenyl-1H-pyrazol-1-yl)-2-(hydroxymethyl)benzenesulfonamide 

Relevant academic research and scientific papers

Method of preparing 1,3-diketone compound by acetyenic ketone

The invention relates to a preparation method of preparing a 1,3-diketone compound by acetyenic ketone. The preparation method comprises the following steps: S1, putting alpha-alkynyl ketone compound,water, gold salt and silver salt in a reaction solvent to obtain a precursor mixture, wherein the molar ratio of the alpha-alkynyl ketone compound, water, gold salt and silver salt is 1: (1-50): (0.001-0.10): (0.002-0.15); and S2, putting the precursor mixture obtained in the S1 to react at a reaction temperature of 0-50 DEG C to obtain the 1,3-diketone compound, wherein the reaction time is 5 min to 48 h. The method is simple in reaction condition, free of acid or alkaline additives and high in yield, and can be applied to modern production on a large scale.

Room-Temperature Coupling/Decarboxylation Reaction of α-Oxocarboxylates with α-Bromoketones: Solvent-Controlled Regioselectivity for 1,2- and 1,3-Diketones

A transition-metal-free and room-temperature coupling/decarboxylation reaction between α-oxocarboxylates and α-bromoketones is reported herein. It represents the first mild and regioselective synthesis of either 1,2- or 1,3-diketones from the same starting materials. Notably, the regioselectivity is simply controlled by solvents. The preliminary experimental data and DFT calculations suggest sequential Darzens-type coupling, alkaline hydrolysis, KOH-promoted oxirane opening and decarboxylation in one pot. This method is efficient for the synthesis of α,β-epoxy-γ-butyrolactone and curcuminoids.

Use of β-Ketocarboxylic Acids for Syntheses of 6-Substituted 4-Hydroxy-2-pyrones and Acyclic β-Diketones

β-Ketocarboxylic acids including β-ketoglutaric acid half-esters were cyclized by treating them with 1,1'-carbonyl-diimidazole to give 6-substituted 3-acyl-4-hydroxy-2-pyrones in good yields. 5-Aryl-3,5-dioxo-1-pentanoic acid and monomethyl malonate gave 6-aryl-4-hydroxy-2-pyrone and dimethyl β-ketoglutarate, respectively, on similar treatment.Anibin, one of the Aniba alkaloids, was synthesized from 5-(3-pyridyl)-4-hydroxy-2-pyrone.In addition, it was confirmed that reaction of magnesium β-ketocarboxylate with acylimidazolide gave the corresponding acyclic β-diketone in excellent yield.Keywords - β-ketocarboxilic acid; biogenetic-type synthesis; 4-hydroxy-2-pyrone; β-polyketide; β-ketoglutaric acid; dehydroacetic acid; anibin; Aniba alkaloid; 3-acyl-4-hydroxy-2-pyrone; β-diketone.

3,5-Cycloalkyl pyrazolium salts as fungicides

There is provided a method for the control of plant pathogenic fungi with certain 3(5) or 3,5-cycloalkyl pyrazolium salts and to a method of protecting plants from fungal attack by applying to the foliage of said plants said pyrazolium salt in fungicidall