55846-72-5

Usage

Type of Compound

Diketone derivative

Common Uses

Flavoring agent in food and beverages
Production of cosmetics and fragrances

Health Concerns

Potential respiratory irritation
Possible respiratory and skin sensitizer

Safety Precautions

Handle and use with caution, follow safety guidelines to minimize exposure and adverse health effects.

Upstream product

• 536-74-3 phenylacetylene 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 772-38-3 4-tert-Butylphenylacetylene 
• 98-88-4 benzoyl chloride 
• 1005385-47-6 3-(4-(tert-butyl)phenyl)-1-phenylprop-2-yn-1-one 
• 932-90-1 Benzaldoxime 
• 671796-41-1 3-[(4-tert-butyl)phenyl]-1-phenylprop-2-yn-1-one 
• 4210-32-6 4-tert-butyl benzonitrile 
• 70-11-1 α-bromoacetophenone 
• 93-58-3 benzoic acid methyl ester 
• 943-27-1 4'-t-butylacetophenone 

Downstream Products

• 101789-39-3 1-(4-(tert-butyl)phenyl)-2-phenylethane-1,2-dione 

Relevant academic research and scientific papers

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.

Variations in the blaise reaction: Conceptually new synthesis of 3-amino enones and 1,3-diketones

Organic compounds with 3-amino enone or 1,3-diketone functional groups are extremely important, as they can be converted into a plethora of heterocyclic or carbocyclic compounds, or can be used as ligands in metal complexes. We have achieved a new, easy, straightforward and convenient synthesis of 3-amino enones and 1,3-diketones starting from aryl/heteroaryl/alkyl nitriles and 1-aryl/alkyl 2-bromoethanones. The reaction is a variation of the classical Blaise reaction, and it works with zinc and trimethylsilyl chloride as an activator. By running the hydrolysis of the reaction intermediate with HCl (3 N aq.) at 0-30 °C or at 100 °C, it is possible to form either 3-amino enones or 1,3-diketones, respectively. The newly developed method was used for the synthesis of avobenzone, an ingredient of sun-screen lotions. Furthermore, an easy synthesis of (Z)-3-amino-1-[4-(tertbutyl) phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one, with UV/Vis absorption characteristics similar to those of avobenzone, was also achieved.

PARTICULATE UV PROTECTION AGENT

The present invention relates to particulate UV protection agents which are obtainable by hydrothermal treatment of a particulate metal oxide and subsequent application of a manganese oxide coating, and to the preparation and use thereof. The present invention furthermore relates to novel compositions, in particular for topical application, which are intended, in particular, for light protection of the skin and/or hair against UV radiation and free-radical-induced stress, and to the use thereof in the above-mentioned cosmetic application.

Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor

Cosmetic/sunscreen compositions contain a combination of at least one dibenzoylmethane sunscreen compound and a photostabilizing amount of at least one dithiolane compound of formula (I) below:

Cosmetic compositions comprising photostabilized dibenzoylmethane compounds and 2-pyrrolidinone-4- carboxy esters

Photostable cosmetic compositions contain, formulated into a cosmetically acceptable vehicle, at least one UV-screening system that includes: (a) at least one dibenzoylmethane compound, and(b) at least one 2-pyrrolidinone-4-carboxy ester compound having the following formula (I): in which: R1 is a linear or branched C1-C20 alkyl radical, andR2 is a linear or branched C1-C20 alkyl radical which optionally includes a C5-C6 ring member, the phenyl radical, the benzyl radical or the phenethyl radical.

Photostable cosmetic compositions comprising dibenzoylmethane/pyrrolidinone compounds

Photostable UV-photoprotecting cosmetic sunscreen compositions contain (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane compound sunscreen, (b) an effective radiation-photostablizing amount of at least one pyrrolidinone compound having the formula (I) below: and, advantageously, at least one liquid fatty phase and at least one lipophilic active sunscreen agent of low solubility, formulated into (c) a cosmetically acceptable support therefor.

Photoprotective cosmetic compositions comprising photostabilized dibenzoylmethane compounds and siloxane-containing arylalkyl benzoate amide compounds

Photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane sunscreen compound and at least one photostabilizing siloxane-containing arylalkyl amide compound of formula (I) below:

Benzoic acid ester compounds, compositions, uses and methods related thereto

Benzoic acid ester compounds of formula (I): wherein R and R1-R5 are as defined in the description, methods for producing them and use thereof in cosmetic, pharmaceutical, personal care and industrial preparations as sunscreens based on photochemical precursor properties of ultraviolet absorbers.

Photostable UV-screening compositions comprising dibenzoylmethane/diarylbutadiene compounds

Topically applicable, photostable cosmetic/dermatological UV-screening compositions comprise (a) at least one photolabile UV-screening dibenzoylmethane compound and (b) a dibenzoylmethane photostabilizing amount of at least one 4,4-diarylbutadiene compound, formulated into a topically applicable, cosmetically/dermatologically acceptable support therefor; the weight ratio of the 4,4-diarylbutadiene compound(s) to the diarylbutadiene compound(s) is characteristically greater than 2.5 and the subject compositions are advantageously devoid of any cinnamate sunscreen.

Dibenzoylmethane sunscreen compositions photostabilized with amphiphilic block copolymers

Topically applicable photostable sunscreen/photoprotective compositions contain at least one dibenzoylmethane UV-sunscreen and an effective photostabilizing amount therefor of at least one amphiphilic block copolymer which comprises at least one nonionic hydrophilic polymer block and at least one hydrophobic polymer block, formulated into a topically applicable, cosmetically acceptable medium therefor.