558465-93-3

Usage

Uses

Used in Chemical Synthesis:
2,5-Dichloro-3-hydroxymethylpyridine is used as a reagent for various chemical synthesis processes. Its unique structure allows it to participate in a range of reactions, making it a valuable component in the creation of more complex molecules.
Used in Scientific Research:
In the field of scientific research, 2,5-dichloro-3-hydroxymethylpyridine is employed as an intermediate in the development of new compounds. Its properties and reactivity are studied to understand its potential applications and to explore its role in chemical reactions.
Used in Industrial Applications:
2,5-Dichloro-3-hydroxymethylpyridine is utilized in industrial settings as a key component in the production of certain chemicals and materials. Its versatility in chemical reactions contributes to its importance in the manufacturing process.
Used in Pharmaceutical Development:
2,5-Dichloro-3-hydroxymethylpyridine is used as a building block in the pharmaceutical industry, where it may be incorporated into the structure of potential drug candidates. Its presence in these compounds can influence their pharmacological properties and therapeutic effects.
Used in Material Science:
In material science, 2,5-dichloro-3-hydroxymethylpyridine is used to develop new materials with specific properties. Its incorporation into these materials can alter their characteristics, such as stability, reactivity, or other physical and chemical properties.

InChI:InChI=1/C6H5Cl2NO/c7-5-1-4(3-10)6(8)9-2-5/h1-2,10H,3H2

Upstream product

• 59782-85-3 2,5-dichloronicotinic acid 
• 176433-49-1 2,5-dichloropyridine-3-carbaldehyde 
• 67754-03-4 methyl 2,5-dichloronicotinate 

Downstream Products

• 1386986-57-7 5-chloro-3-(methoxymethyl)picolinic acid 
• 1386986-06-6 5-chloro-3-methoxymethyl-pyridine-2-carbonitrile 
• 1386984-01-5 5-chloro-3-methoxymethyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide 
• 1386985-56-3 ((R)-5-{5-[(5-chloro-3-methoxymethyl-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

The invention is concerned with the compounds of formula I and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS

The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in pharmaceutically acceptable salt form, to their preparation, to their medical use and to medicaments comprising them.

Bridged 5,6,7,8-tetrahydro-1,6-naphthyridines, analogues of huperzine A: Synthesis, modelling studies and evaluation as inhibitors of acetylcholinesterase

Derivatives of 6,8-bridged 5,6,7,8-tetrahydro-1,6-naphthyrid-ines, designed as analogues of huperzine A, were synthe-sised and evaluated as inhibitors of acetylcholinesterase. In a first approach, C3-bridged naphthyridines were constructed by internal nucleophilic aromatic substitution of 2-chloro-3-(1-piperidinylmethyl)pyridine precursors containing a 3-CO 2Me group on the 1-piperidinyl ring moiety. Alternatively, ring-closing metathesis on 6,8-diallyl-substituted tetrahydro-1,6-naphthyridines was applied to construct an unsaturated C4 bridge. Some of the target compounds showed inhibition of acetylcholinesterase but lower than that of huperzine A. The relative order of inhibition activities could be rationalised by comparative docking simulation studies on the basis of the known crystal structure of the ace-tylcholinesterase-huperzine A complex.

BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS

Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.