558639-28-4Relevant academic research and scientific papers
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
Cheung, Kwai-Ming J.,Matthews, Thomas P.,James, Karen,Rowlands, Martin G.,Boxall, Katherine J.,Sharp, Swee Y.,Maloney, Alison,Roe, S. Mark,Prodromou, Chrisostomos,Pearl, Laurence H.,Aherne, G. Wynne,McDonald, Edward,Workman, Paul
, p. 3338 - 3343 (2007/10/03)
High-throughput screening identified the 3,4-diarylpyrazole CCT018159 as a novel and potent (7.1 μM) inhibitor of Hsp90 ATPase activity. Here, we describe the synthesis of CCT018159 and a number of close analogues together with data on their biochemical p
