55912-03-3

Usage

Uses

Used in Pharmaceutical Development:
4-hydroxyderricin is used as a pharmaceutical candidate for its potential therapeutic effects, including anti-cancer, anti-microbial, and anti-viral properties. Its antioxidant and anti-inflammatory characteristics contribute to its potential as a novel treatment for various diseases and conditions.
Used in Natural Health Products:
4-hydroxyderricin is used as an ingredient in natural health products due to its beneficial properties, such as neuroprotection and anti-obesity effects. Its presence in these products can offer consumers an alternative approach to maintaining health and well-being.
Used in Medical Research:
4-hydroxyderricin is utilized in medical research to explore its potential applications in treating various diseases and conditions. Its diverse properties, such as antioxidant, anti-inflammatory, and neuroprotective effects, make it a valuable subject for scientific investigation and potential drug development.
Used in Nutritional Supplements:
4-hydroxyderricin is used as a component in nutritional supplements to provide consumers with the health benefits associated with its antioxidant and anti-inflammatory properties. Its inclusion in these products can support overall health and contribute to the prevention of certain diseases.

InChI:InChI=1/C21H22O4/c1-14(2)4-10-18-20(25-3)13-11-17(21(18)24)19(23)12-7-15-5-8-16(22)9-6-15/h4-9,11-13,22,24H,10H2,1-3H3/b12-7+

Upstream product

• 1092462-95-7 4'-methoxy-4-methoxymethoxy-2'-prenyloxychalcone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 52601-06-6 1-(2-hydroxy-4-methoxy-3-(3-methyl-butyl-2-ene-1-yl)phenyl)ethanone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 128961-25-1 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one 
• 123-08-0 4-hydroxy-benzaldehyde 
• 19825-40-2 2,4-Dihydroxy-3-C-prenylacetophenone 
• 54730-26-6 4-methoxymethoxy-3-(3,3-dimethylallyl)-2-hydroxyacetophenone 
• 1314539-20-2 2'-prenyloxy-4'-methoxymethoxyacetophenone 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 1092462-94-6 2'-hydroxyl-4'-methoxy-4-methoxymethoxy-3'-prenyl-chalcone 
• 1393921-61-3 1-(4-methoxy-2-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethanone 

Downstream Products

• 791112-99-7 4-tetrahydropyranyloxy-2'-hydroxy-3'-prenyl-4'-methoxychalcone 
• 132998-83-5 (E)-1-(2-hydroxy-3-(2-hydroxy-3-methylbut-3-en-1-yl)-4-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 132998-84-6 xanthoangelol E 
• 791113-18-3 4-acetoxy-2'-hydroxy-3'-prenyl-4'-methoxychalcone 
• 62536-71-4 4'-methoxy-4.2'-diacetoxy-trans-chalcone 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of four natural chalcones and their derivatives

Four natural chalcones bearing hydroxyisoprenyl or prenyl groups, named Paratocarpin E (2), Xanthoangelol D (3), Angusticornin A (4) and Kanzonol C (5), were prepared by employing the Claisen-Schmidt condensation as the key step. In an attempt to investigate the effect of the hydroxyisoprenyl group on biological activity, two of their derivatives were also prepared for antibacterial activity research. The synthesized compounds were investigated for their expected antibacterial activities against Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) as well as Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa). Paratocarpin E (2) was found to be the most potent against two Gram positive bacteria while the majority of the remaining compounds showed promising activity as well. However, all of the compounds were inactive against both Gram-negative bacteria.

Preparation method and application of natural product Xanthoangelol D and derivative thereof

The invention discloses a preparation method and application of an isopentenyl chalcone natural product and a derivative thereof. The structural general formula (I) and (II) of the isopentenyl chalcone natural product and the derivative thereof are as follows. Compared with a novel isopentenyl chalcone derivative, the obtained natural product Xanthoangelol D has inhibitory activity improved to a certain degree on bacillus subtilis. The preparation rout of the preparation method has fewer process steps, raw materials are easily available, and the preparation method is suitable for industrial production.

Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.

Synthesis of 4-hydroxyderricin and related derivatives

Naturally occurring chalcones, namely 4-hydroxyderricin (1), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4), were first synthesized and evaluated for antibacterial activities.