5592-17-6Relevant academic research and scientific papers
Polystyrene-supported 2-bromoallyl sulfone as an efficient reagent for synthesis of 3,5-disubstituted isoxazoles
Zhang, Liang,Mao, Xue-Chun,Wang, Qiu-Ying,Pan, Yang,Chen, Jun-Min
, p. 142 - 148 (2019/08/26)
A facile method has been developed for the solid-phase organic synthesis of 3,5-disubstituted isoxazoles from polystyrene-supported 2-bromoallyl sulfone. The advantages of this method include a straightforward and convenient procedure, high product yield,
General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies
Fernandes, Alessandra A. G.,da Silva, Amanda F.,Okada, Celso Y.,Suzukawa, Vitor,Cormanich, Rodrigo A.,Jurberg, Igor D.
, p. 3022 - 3034 (2019/05/17)
A general platform for the conversion of isoxazol-5-ones to 3,5-disubstituted isoxazoles has been developed via a two-step strategy. The first step leads to the formation of 5-(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl-, heteroaryl-, alkyl-, alkenyl-, alkynyl- and aryl-chains can be installed via nucleophilic substitutions or palladium catalyzed cross-coupling reactions.
3-aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation
Salomone, Antonio,Scilimati, Antonio,Vitale, Paola
, (2015/02/02)
3-Aryl-5-hydroxy-5-vinyl-2-isoxazolines were synthesized by reacting aryl nitrile oxides with the lithium enolate of methyl vinyl ketone (MVK) at -78 °C. Fair to good yields are obtained in the case of aryl nitrile oxides bearing electron-withdrawing grou
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: Synthesis and reactivity
Di Nunno, Leonardo,Scilimati, Antonio,Vitale, Paola
, p. 11270 - 11278 (2007/10/03)
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline has been synthesized by reacting benzonitrile oxide with the enolate ion of methyl vinyl ketone. From 5-hydroxy-5-vinyl-2-isoxazoline, 5-vinylisoxazole was then quantitatively obtained by dehydration-aromatization
1,3-Dipolar cycloaddition of nitrile oxides to 1-phenylsulfonyl-1,3-butadienes: Synthesis of 3-(4,5-dihydroisoxazol-5-yl)pyrroles
Hwang, Sung Hee,Kurth, Mark J
, p. 53 - 56 (2007/10/03)
Novel heterocyclic compounds containing the 3-(4,5-dihydroisoxazol-5-yl)pyrrole ring system were synthesized in good yields (66-78%) by regioselective 1,3-dipolar cycloaddition of nitrile oxides to 1-phenylsulfonyl-1,3-dienes followed by Barton-Zard pyrrole annulation.
