5595-63-1

Upstream product

• 693-02-7 hex-1-yne 
• 110-62-3 pentanal 
• 98-86-2 acetophenone 
• 71-41-0 pentan-1-ol 
• 98-85-1 1-Phenylethanol 
• 1129-65-3 (hex-1-yn-1-yl)benzene 
• 774-48-1 (diethoxymethyl)benzene 
• 27975-74-2 ethyl-(α-chloro-benzyl)-ether 
• 70-11-1 α-bromoacetophenone 
• 13944-95-1 2-(phenacylsulfanyl)-1,3-benzothiazole 
• 72206-40-7 1-phenylhept-1-yn-3-ol 
• 1071001-96-1 1-Ethoxy-1-phenyl-hepta-1,2-dien 
• 1902-95-0 ethyl-(1-phenyl-hept-2-ynyl)-ether 

Downstream Products

• 173277-04-8 3-(methoxyamino)-1-phenylheptan-1-one 
• 406189-07-9 ((2R,3S)-3-Butyl-oxiranyl)-phenyl-methanone 
• 1334714-57-6 1-phenyl-3-(phenylamino)heptan-1-one 
• 1298064-81-9 C₁₉H₂₁N₃O 

Relevant academic research and scientific papers

Efficient catalytic performance of calcined tungstophosphoric acid for the Claisen-Schmidt condensation under solvent-free reaction

Effect of calcination of tungstophosphoric acid catalyst was evaluated in terms of the synthesis of chalcone derivatives via Claisen-Schmidt condensation using the reaction of acetophenone and several substituted aldehydes. The catalyst was characterized before and after calcination by FT-IR to assess the effectiveness of the synthesis of the desired products. The calcined tungstophosphoric acid catalyst (HPW-CL) showed a better performance and high yield of Claisen-Schmidt products in a short period of time. It was also found out that the calcined tungstophosphoric acid provides a chemo selective, efficient and environmentally benign synthesis of chalcone in an excellent yield in a solvent-free system.

Co-N-C Catalyst for C-C Coupling Reactions: On the Catalytic Performance and Active Sites

C-C bond-forming reactions are important in chemistry for construction of complex large molecules from readily available simple substrates. However, they usually involve the employment of organic halides and suffer from toxic or environmental issues. We report an efficient and environmentally benign methodology-aerobic oxidative cross-coupling of primary and secondary alcohols-to directly produce α,β-unsaturated ketones that are key intermediates for synthesis of agrochemical, pharmaceutical, and other fine chemicals. A noble-metal-free Co-N-C catalyst, derived from pyrolysis of cobalt-phenanthroline complexes on a mesoporous carbon support, is developed toward the target reactions and shows high catalytic activity (turnover frequency of 3.8 s-1 based on Co single atoms, surpassing the state of art in the literature), good recyclability, and wide applicability to diverse substrates (28 examples). The active sites in the Co-N-C catalyst are proposed to be Co single atoms bonded with N within graphitic sheets.

A Desulfonylative Approach in Oxidative Gold Catalysis: Regiospecific Access to Donor-Substituted Acyl Gold Carbenes

Donor-substituted acyl gold carbenes are challenging to access selectively by gold-promoted intermolecular oxidation of internal alkynes as the opposite regioisomers frequently predominate. By using alkynyl sulfones or sulfonates as substrates, the oxidative gold catalysis in the presence of substituted pyridine N-oxides offers regiospecific access to acyl/aryl, acyl/alkenyl, and acyl/alkoxy gold carbenes by in situ expulsion of sulfur dioxide. The intermediacies of these reactive species are established by their reactivities, including undergoing further oxidation by the same oxidant, cyclopropanation of styrenes, engaging in a [3+2] cycloaddition with α-methylstyrene, and conversion into dienones. Accept it: A desulfonylative approach was developed to regiospecifically access these underexplored acyl gold carbenes from either alkynyl aryl/alkenyl sulfones or alkynyl sulfonate substrates. The reactivities of these donor- and acceptor-substituted carbenes are examined.

Optically active epoxy compounds and processes for their production

An optically active epoxyenone derivative of the following formula (1): wherein R1 is a methyl group, an ethyl group or a C3-10 branched, linear or cyclic alkyl group, and R2 is a phenyl group, a substituted phenyl group o

On tertiary stibine I. Reaction of ω-bromoacetophenone with aldehydes mediated by diphenylantimonyorganometallic reagents

In the presence of diphenylantimonymagnesium, various aldehydes react readily with ω-bromoacetophenone to form α,β-unsaturated ketones in good yields.

Rearrangement of Allylic and Propargylic Alcohols Catalyzed by the Combined Use of Tetrabutylammonium Perrhenate(VII) and p-Toluenesulfonic Acid

Allylic rearrangement and/or dehydration of allylic alcohols proceed by the use of a catalytic amount of tetrabutylammonium perrhenate and p-toluenesulfonic acid.Treatment of propargylic alcohols with the above reagents affords the rearranged products, α,β-unsaturated carbonyl compounds.

α-ENONE BY THE REACTION OF ALDEHYDE AND α-BROMOKETONE WITH TRI-n-BUTYLSTIBINE

α-Enones were readily obtained from the reaction of α-bromoketone with aldehydes mediated by tri-n-butylstibine.

CARBON-CARBON BOND FORMATION VIA PHOSPHINE-INITIATED CLEAVAGE OF β-OXOSULFIDES

2-(Phenacylthio)benzothiazole (1) reacted with aldehyde or ketone in the presence of tri-n-butylphosphine at 80 deg C to give α,β-enone and 2-mercaptobenzothiazole in good yield.The reaction scheme for this new type of enolate ion formation via C-S bond cleavage is also described.