55969-94-3Relevant academic research and scientific papers
Hydroxybenzothiophene ketones are efficient pre-mRNA splicing modulators due to dual inhibition of Dyrk1A and Clk1/4
Schmitt, Christian,Miralinaghi, Parisa,Mariano, Marica,Hartmann, Rolf W.,Engel, Matthias
, p. 963 - 967 (2014)
Dysregulated usage of pre-mRNA splicing sites contributes to the progression of cancer, neurodegenerative diseases, and viral infections. Serine/arginine-rich (SR) proteins play major roles in the splice site recognition and are largely regulated by phosp
Design, synthesis and characterization of structurally dynamic cyclic: N, S -acetals
Kirkeby, Emily K.,Roberts, Andrew G.
supporting information, p. 9118 - 9121 (2020/08/26)
We report the synthesis, characterization and comparison of a series of electronically perturbed, cyclic N,S-acetals. Inspired by electrophilic auxiliaries utilized for amine capture and concomitant peptide ligation, we studied these N,S-acetal systems and evaluated their propensity to generate zwitterionic intermediates in situ. Certain N,S-acetals in this study exhibit structurally dynamic properties through a solvent and pH-dependent ability to ring-open and ring-close via C1-S bond ionization at room temperature.
Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[ b ]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents
Romagnoli, Romeo,Baraldi, Pier Giovanni,Lopez-Cara, Carlota,Preti, Delia,Aghazadeh Tabrizi, Mojgan,Balzarini, Jan,Bassetto, Marcella,Brancale, Andrea,Fu, Xian-Hua,Gao, Yang,Li, Jun,Zhang, Su-Zhan,Hamel, Ernest,Bortolozzi, Roberta,Basso, Giuseppe,Viola, Giampietro
, p. 9296 - 9309 (2014/01/06)
The biological importance of microtubules make them an interesting target for the synthesis of antitumor agents. The 2-(3′,4′,5′- trimethoxybenzoyl)-5-aminobenzo[b]thiophene moiety was identified as a novel scaffold for the preparation of potent inhibitor
Light-triggered self-assembly of gold nanoparticles based on photoisomerization of spirothiopyran
Shiraishi, Yasuhiro,Tanaka, Kazuya,Shirakawa, Eri,Sugano, Yoshitsune,Ichikawa, Satoshi,Tanaka, Shunsuke,Hirai, Takayuki
supporting information, p. 8304 - 8308 (2013/09/02)
Give it some stick: UV irradiation of spirothiopyran in an aqueous solution of gold nanoparticles (AuNPs) gives AuNP aggregates. The aggregate size is tuned by the photoirradiation time and the aggregation is facilitated by the covalent binding of photois
A novel domino condensation-intramolecular nucleophilic cyclization approach towards annulated thiochromenes
Voskressensky, Leonid G.,Sokolova, Ekaterina A.,Festa, Alexey A.,Varlamov, Alexey V.
supporting information, p. 5172 - 5173 (2013/09/02)
A one-pot protocol towards previously unreported derivatives of thiochromeno [2′,3′:4,5] imidazo[2,1-a]isoquinoline via a domino reaction of isoquinoline-derived iminium salts and α-mercapto benzaldehydes is elaborated.
PHOTOCHROMISM. SYNTHESIS AND PROPERTIES OF INDOLINOSPIROBENZOTHIOPYRANS
Arakawa, Sei'ichi,Kondo, Hirofumi,Seto, Jun'etsu
, p. 1805 - 1808 (2007/10/02)
Novel photochromic compounds, indolinospirobenzothiopyrans, were prepared and their properties in polymer films were examined.The absorption bands of the colored form lie around 100 nm deeper in the long-wave region of the spectrum than are the case with the common spiropyrans.
