5597-52-4Relevant academic research and scientific papers
The structure - Activity relationship of the antimalarial ozonide arterolane (OZ277)
Dong, Yuxiang,Wittlin, Sergio,Sriraghavan, Kamaraj,Chollet, Jacques,Charman, Susan A.,Charman, William N.,Scheurer, Christian,Urwyler, Heinrich,Tomas, Josefina Santo,Snyder, Christopher,Creek, Darren J.,Morizzi, Julia,Koltun, Maria,Matile, Hugues,Wang, Xiaofang,Padmanilayam, Maniyan,Tang, Yuanqing,Dorn, Arnulf,Brun, Reto,Vennerstrom, Jonathan L.
, p. 481 - 491 (2010)
The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum in vitro.Weak base functional groups were not required for high antimalarial potency, but they were essential for high antimalarial efficacy in P. berghei-infected mice. Five new ozonides with antimalarial efficacy and ADME profiles superior or equal to that of arterolane were identified.
Trans-Selective and Switchable Arene Hydrogenation of Phenol Derivatives
Bergander, Klaus,Glorius, Frank,Heusler, Arne,Wollenburg, Marco
, p. 11365 - 11370 (2020/11/24)
A trans-selective arene hydrogenation of abundant phenol derivatives catalyzed by a commercially available heterogeneous palladium catalyst is reported. The described method tolerates a variety of functional groups and provides access to a broad scope of trans-configurated cyclohexanols as potential building blocks for life sciences and beyond in a one-step procedure. The transformation is strategically important because arene hydrogenation preferentially delivers the opposite cis-isomers. The diastereoselectivity of the phenol hydrogenation can be switched to the cis-isomers by employing rhodium-based catalysts. Moreover, a protocol for the chemoselective hydrogenation of phenols to cyclohexanones was developed.
A butene liquid crystal compound and its preparation method
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, (2016/10/10)
The invention relates to a butylene type liquid crystal compound and a preparation method of the same. Such compounds are novel negative liquid crystal materials with low viscosity and high absolute value of dielectric constant, have better chemical stability and better stability in light environment and high-temperature environment, and have very high application valve. The butylene type liquid crystal compound is structured as a structural formula shown in the specification, wherein in the structural formula of the compound, R1 refers to hydrogen atom, linear alkyl with 1-8 carbon atoms or linear alkenyl with 2-8 carbon atoms, or alkoxy or alkenyloxy formed by substituting one or two nonadjacent CH2 in the linear alkyl or the linear alkenyl with oxygen atoms, and 0-4 hydrogen atoms in the R1 group are substituted by fluorine; R2 refers to hydrogen atoms or linear alkyl with 1-8 carbon atoms, and 0-4 hydrogen atoms in the R2 group are substituted by fluorine; n = 1 to 2.
