5597-54-6

Upstream product

• 5597-52-4 methyl 3-(4-oxocyclohexyl)propionate 
• 960370-91-6 C₁₈H₂₄O₃ 
• 5597-60-4 3-(4-methoxycyclohexa-1,4-dien-1-yl)propan-1-ol 
• 5597-51-3 4-hydroxy-3-cyclohexylpropionic acid methyl ester 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 5597-61-5 4-(3-Hydroxypropyl)-cyclohexen-3-on 

Downstream Products

• 471269-91-7 4-[3-(tert-butyldiphenylsilyloxy)propyl]cyclohexanone 
• 569351-28-6 (+/-)-3-[3-(4-tert-butylcarbamylphenoxy)propyl]-9-methyl-1,2,3,4-tetrahydrocarbazole 
• 471269-92-8 rac-5-[3-(tert-butyldiphenylsilyloxy)propyl]=2-hydroxycyclohex-1-enecarboxylic acid methyl ester 
• 471269-84-8 rac-5-[3-(tert-butyldiphenylsilyloxy)propyl]-2-trifluoromethylsulfonyloxycyclohex-1-enecarboxylic acid methyl ester 
• 471270-12-9 C₅₄H₆₈O₅Si₂ 
• 471269-99-5 3-[5-(tert-butyl-diphenyl-silanyloxy)-3,3-dimethyl-2-vinyl-7-oxa-bicyclo[2.2.1]hept-1-yl]-6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one 
• 471270-10-7 Acetic acid (S)-[(1R,2S,4R,5S)-5-(tert-butyl-diphenyl-silanyloxy)-3,3-dimethyl-2-vinyl-7-oxa-bicyclo[2.2.1]hept-1-yl]-{4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2-formyl-cyclohex-1-enyl}-methyl ester 
• 471270-05-0 (S)-[(1R,2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-3,3-dimethyl-2-vinyl-7-oxa-bicyclo[2.2.1]hept-1-yl]-{4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2-hydroxymethyl-cyclohex-1-enyl}-methanol 
• 471270-11-8 Acetic acid (S)-[(1R,2S,4R,5S)-5-(tert-butyl-diphenyl-silanyloxy)-3,3-dimethyl-2-vinyl-7-oxa-bicyclo[2.2.1]hept-1-yl]-{4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2-vinyl-cyclohex-1-enyl}-methyl ester 
• 471270-08-3 Acetic acid (S)-[(1R,2S,4R,5S)-5-(tert-butyl-diphenyl-silanyloxy)-3,3-dimethyl-2-vinyl-7-oxa-bicyclo[2.2.1]hept-1-yl]-{4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2-hydroxymethyl-cyclohex-1-enyl}-methyl ester 
• 471270-18-5 C₅₅H₆₈O₇Si₂ 
• 471270-16-3 C₅₄H₆₈O₇Si₂ 
• 1053635-24-7 C₅₄H₆₆O₇Si₂ 
• 471270-06-1 {2-(tert-butyl-dimethyl-silanyloxymethyl)-4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-cyclohex-1-enyl}-[5-(tert-butyl-diphenyl-silanyloxy)-3,3-dimethyl-2-vinyl-7-oxa-bicyclo[2.2.1]hept-1-yl]-methanol 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN

Bifunctional compounds, which find utility as modulators of androgen receptor (AR), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds AR, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.