5599-21-3

Upstream product

• 50-01-1 guanidine hydrochloride 
• 43002-64-8 ethyl 4-methylbenzimidate hydrochloride 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

METHOD FOR PRODUCING 2-AMINO-1,3,5-TRIAZINE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing 2-amino-4,6-di-substituted 1,3,5-triazine simply and under a mild condition. SOLUTION: Guanidine or a salt thereof is added to a mixture including a nitrile compound and a base and reacted therewith to produce 2-amino-4,6-di-substituted 1,3,5-triazine. Alternatively, a mixture (or a mixed liquid) including guanidine or a salt thereof and a solvent may be added to a mixture (or a mixed liquid) including a nitrile compound, a base and a solvent and reacted therewith. The base may be an alkali metal hydride, for example, sodium hydride. After completing the reaction, a step of depositing a deposit by adding a poor solvent to the reaction mixture and a step of separating the deposited deposit may be included. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Base-mediated synthesis of unsymmetrical 1,3,5-triazin-2-amines via three-component reaction of imidates, guanidines, and amides or aldehydes

A simple and efficient method for the basemediated synthesis of unsymmetrical 1,3,5-triazin-2-amines has been developed. The protocol uses readily available imidates, guanidines, and amides or aldehydes as the starting materials, cesium carbonate as the base, no catalyst or additive is required, and the three-component reaction provides diverse 1,3,5-triazin-2-amines in moderate to good yields with tolerance of wide functional groups.