55991-68-9

Upstream product

• 55558-81-1 4-(4-methylphenyl)-2,4-dioxobutanoic acid 
• 79-37-8 oxalyl dichloride 
• 54731-27-0 1-p-methylphenyl-1-trimethylsiloxyethene 
• 766-97-2 4-n-methylphenylacetylene 
• 1352131-43-1 5-hydroxy-5-(4-methylphenylethynyl)-N,N'-diphenylimidazolidine-2,4-dione 
• 122-00-9 para-methylacetophenone 
• 103344-69-0 (Z)-2-hydroxy-4-oxo-4-p-tolyl-2-butenoic acid 

Downstream Products

• 130421-42-0 2,4-Dioxo-N-thiazol-2-yl-4-p-tolyl-butyramide 
• 130421-37-3 2,4-Dioxo-N-pyridin-2-yl-4-p-tolyl-butyramide 
• 130421-46-4 2,4-Dioxo-N-pyrimidin-2-yl-4-p-tolyl-butyramide 
• 132680-82-1 C₁₈H₁₅NO₅ 
• 132680-81-0 C₁₆H₁₂N₂O₇ 
• 132680-80-9 C₁₈H₁₄N₂O₇ 
• 77092-08-1 2-(4-Nitro-phenyl)-6-p-tolyl-[1,3]dioxin-4-one 
• 77092-07-0 2-(4-Bromo-phenyl)-6-p-tolyl-[1,3]dioxin-4-one 
• 77092-18-3 2-Methyl-2,6-di-p-tolyl-[1,3]dioxin-4-one 
• 77092-21-8 2-Bromomethyl-2-phenyl-6-p-tolyl-[1,3]dioxin-4-one 
• 97180-96-6 2-Methoxycarbonylmethylene-5-p-tolyl-2,3-dihydrofuran-3-one 
• 98157-46-1 2,2-dimethyl-6-(4-methylphenyl)-4H-1,3-dioxin-4-one 
• 125103-61-9 N-(3-Cyano-phenyl)-2,4-dioxo-4-p-tolyl-butyramide 
• 113308-02-4 N-(Cyano-dimethyl-methyl)-2,4-dioxo-4-p-tolyl-butyramide 

Relevant academic research and scientific papers

Furan-2,3-diones as masked dipoles: synthesis of isotetronic acids and mechanistic considerations

The formal dipolar behaviour of furan-2,3-diones is illustrated by their reaction with ethyl glyoxylate under Lewis basic activation uniquely, giving access to isotetronic derivatives. The Janus-type nature of the activated species, both nucleophilic and

Diphenylparabanic acid as a synthon for the synthesis of α-diketones and α-ketocarboxylic acids

Diphenylparabanic acid was found to react with >2 equiv of organolithiums at -78 °C to effectively give the corresponding symmetrical α-diketones. However, upon treatment with 1 equiv of organolithium, the parabanic acid gave mainly 5-substituted 5-hydroxyimidazolidine-2,4-diones. On the other hand, Grignard reagents were less reactive toward the parabanic acid at low temperature, and selectively gave the corresponding 5- hydroxyimidazolidine-2,4-diones even if more than 1 equiv of the reagents was used. A tandem process in which the parabanic acid was first reacted with a Grignard reagent and then reacted in one-pot with an organolithium effectively gave the unsymmetrical α-diketone. 5-Substituted 5-hydroxyimidazolidine-2, 4-diones were useful as versatile precursors for preparing α- ketocarboxylic acids as well as unsymmetrical α-diketones.

Reactions of acylpyruvic acids and 2,3-dihydrofuran-2,3-diones with 2,3-diaminopyridine

Acylpyruvic acids readily react with 2,3-diaminopyridine to form (Z)-3-acylmethylene-1H-3,4-dihydropyrido[2,3-b]pyrazin-2-ones. 5-Aryl-2,3-dihydrofuran-2,3-diones which can be regarded as lactones derived from γ-enolized aroylpyruvic acids react with 2,3-diaminopyridine under mild conditions, yielding regioisomeric (Z)-2-aroylmethylene-4H-1,2-dihydropyrido[2,3-b]pyrazin-3-ones. The structure of the products and reaction chemoselectivity are discussed.

1,3,4,6-Tetracarbonyl compounds. 3. Synthesis, structural features, and antimicrobial activity of 1,6-diaryl-3,4-dihydroxy-2,4-hexadiene-1,6-diones

The Wittig reaction of 5-aryl-2,3-dihydro-2,3-furandiones with aroylmethylenetriphenylphosphoranes is regioselective and leads to the formation of 5-aryl-2-aroylmethylene-2,3-dihydro-3-furanones. In the presence of acid the products react with water, givi

Reactions of 5-aryl-furan-2,3-diones with acylmethylenetriphenylphosphoranes: Synthesis and biological activity of 3(2H)-furanone derivatives

The Wittig reaction of 5-aryl-furan-2,3-diones 1 with acylmethylenetriphenylphosphoranes 2 conducted by heating under reflux in benzene solutions, proceeded regiospecifically to afford 2-acylmethylene-5-aryl-3(2H)-furanones 5 in good yields. When the star

Synthesis and 13C FT NMR spectroscopy of furan-2,3-dione derivatives

Substituted furan-2,3-diones were obtained by condensation of oxalyl chloride with silyl enol ether of para-substituted acetophenones (R = H, CH3, OCH3, Cl, Br, F), propiophenone, 1-tetralone, 6-methoxytetralone and 1-benzosuberone.The spectroscopic data obtained from IR, UV, 1H and 13C NMR studies are quite similar whichever are the substituents. furan-2,3-dione / 1H and 13C NMR / UV and IR spectra