56003-60-2

Upstream product

• 2403-57-8 1-(2-methylprop-1-en-1-yl)pyrrolidine 
• 2372-98-7 3-fluoro-3-buten-2-one 
• 57039-70-0 4,4-Dimethyl-6-formylcyclohex-2-en-1-one 
• 1073-13-8 4,4-dimethylcyclohexenone 

Downstream Products

• 63577-41-3 1-isopropylidene-4,4-dimethyl-2,5-cyclohexadiene 
• 113553-90-5 1-fluoro-5,5-dimethyl-2-piperidino-1,3-cyclohexadiene 
• 928768-29-0 triethyl-(2-fluoro-4,4-dimethylcyclohexa-1,5-dienyloxy)-silane 
• 1073-13-8 4,4-dimethylcyclohexenone 
• 108-94-1 cyclohexanone 

Relevant academic research and scientific papers

Exploiting a Difference in Leaving Group Ability: An Approach to β-Substituted Monofluoroalkenes Using gem-Chlorofluoropropenes

The superior nucleofuge character of chlorine over fluorine was taken advantage of in the selective SN2′ substitution reaction of gem-chlorofluoropropenes, allowing for the clean formation of β-substituted monofluoroalkenes under metal-free conditions. Numerous N-, S-, O-, and C-nucleophiles behaved nicely in this system. Further synthetic transformations of selected monofluoroalkenes were also accomplished.

Micellar-system-mediated direct fluorination of ketones in water

A micellar system was developed and applied for direct regioselective fluorination of a variety of cyclic and acyclic ketones to α-fluoroketones in water as reaction medium with Selectfluor F-TEDA-BF4 as fluorinating reagent. The inexpensive ionic amphiphile sodium dodecyl sulfate (SDS) was found to be an excellent promoter for fluorofunctionalization of hydrophobic ketones without prior activation or use of acid catalysts. Georg Thieme Verlag Stuttgart.

Enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers

An enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers is reported. This reaction provides a stereoselective and efficient approach to allylated tertiary α-fluoroketones from achiral fluorinated precursors. A variety of cycl

Direct α-fluorination of ketones using N-F reagents

The use of 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Accufluor NFTh) as a fluorine atom transfer reagent and methanol as solvent enabled direct regiospecific fluorofunctionalization of the α-carbonyl position in ketones w