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Usage

Uses

Used in Organic Synthesis:
(3-methylthiophen-2-yl)(phenyl)methanone is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique structure allows for versatile reactions and the formation of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (3-methylthiophen-2-yl)(phenyl)methanone serves as a valuable starting material for the synthesis of biologically active molecules. Its potential to be modified and combined with other compounds makes it a promising candidate for drug development.
Used as an Anti-inflammatory Agent:
(3-methylthiophen-2-yl)(phenyl)methanone has been studied for its potential pharmacological properties, including its use as an anti-inflammatory agent. Its ability to reduce inflammation can be beneficial in the treatment of various conditions.
Used as an Analgesic Agent:
Additionally, (3-methylthiophen-2-yl)(phenyl)methanone has shown potential as an analgesic agent, which can help alleviate pain. This property makes it a candidate for the development of new pain management therapies.
Overall, (3-methylthiophen-2-yl)(phenyl)methanone is an important and versatile chemical compound with potential applications in various fields, including organic synthesis, pharmaceutical research, and medicine.

Upstream product

• 616-44-4 3-Methylthiophene 
• 98-88-4 benzoyl chloride 
• 93-97-0 benzoic acid anhydride 
• 5834-16-2 3-methyl-2-thiophenecarboxaldehdye 
• 108-86-1 bromobenzene 

Relevant academic research and scientific papers

Coupling of aromatic aldehydes with aryl halides in the presence of nickel catalysts with diazabutadiene ligands

Nickel catalysts with diazabutadiene ligands promote cross-coupling of benzaldehydes with aryl halides in the presence of zinc as reducing agent, which leads to the corresponding benzhydrols and benzophenones. The benzophenone percentage considerably increases when lithium chloride additive is used.

Preparation of acylthiophenes by iron(III) chloride catalyzed reactions of tris(2-thienyl)stibanes with acyl chlorides

The reactions of tris(2-thienyl)stibanes with various acyl chlorides, using a catalytic amount of iron(III) chloride, afforded 2-acylthiophenes. Iron(III) chloride is presumed to act as a Lewis acid, and the ipso substituent of each 2-thienyl group of tris(2-thienyl)stibane is replaced with an acyl group. The reaction is highly atom-efficient in that all three thiophene rings of tris(2-thienyl)stibane take part in the reaction. The reaction procedure is so simple that it can also be carried out under solvent-free and aerobic conditions.

A highly active ytterbium(III) methide complex for truly catalytic Friedel-Crafts acylation reactions

The Friedel-Crafts acylation of anisole with acetic anhydride using ytterbium(III) tri[tris(nonafluorobutanesulfonyl)methide] was studied with respect to catalyst loading. A strong inhibitory effect due to the product became apparent from doping experiments and from examination of the kinetic data. This understanding allowed catalyst loadings to be reduced to as little as 0.1 mol% for effective acylation under a suitable temperature and pressure regime.