5601-67-2

Usage

Synthesis Reference(s)

Tetrahedron, 23, p. 3645, 1967 DOI: 10.1016/0040-4020(67)80010-3

Upstream product

• 17301-57-4 13,13-dibromobicyclo<10.1.0>tridecane 
• 5601-66-1 cis-13,13-dibromobicyclo<10.1.0>tridecane 
• 5601-66-1 trans-13,13-dibromobicyclo<10.1.0>tridecane 
• 6573-70-2 (E/Z)-cyclotridecene 
• 1501-82-2 cyclododecene 

Downstream Products

• 56175-27-0 (E)-15,15-Dimethyl-bicyclo[11.2.0]pentadec-12-en-14-one 
• 56175-28-1 (Z)-15,15-Dimethyl-bicyclo[11.2.0]pentadec-12-en-14-one 
• 832-10-0 cyclotridecanone 
• 75805-78-6 (E)-13-Chloro-1-phenylselanyl-cyclotridecene 
• 133295-22-4 (Z)-20-(Toluene-4-sulfonyl)-20-aza-tricyclo[11.7.0.0^14,19]icosa-12,14⁽¹⁹⁾,15,17-tetraene 
• 30651-70-8 (3E,5E)-4,5-diethylocta-3,5-diene 
• 1258601-56-7 C₂₆H₄₆ 
• 1258601-79-4 3-(1-ethylbut-1-en-1-yl)cyclotridecene 

Relevant academic research and scientific papers

Palladium- and Rhodium-Catalyzed Dynamic Kinetic Resolution of Racemic Internal Allenes Towards Chiral Pyrazoles

A complementing Pd- and Rh-catalyzed dynamic kinetic resolution (DKR) of racemic allenes leading to N-allylated pyrazoles is described. Such compounds are of enormous interest in medicinal chemistry as certified drugs and potential drug candidates. The new methods feature high chemo-, regio- and enantioselectivities aside from displaying a broad substrate scope and functional group compatibility. A mechanistic rational accounting for allene racemization and trans-alkene selectivity is discussed.

Rhodium-Catalyzed Parallel Kinetic Resolution of Racemic Internal Allenes Towards Enantiopure Allylic 1,3-Diketones

A rare case of a parallel kinetic resolution of racemic 1,3-disubstituted allenes by means of a rhodium-catalyzed addition to 1,3-diketones furnishing enantiopure allylic 1,3-diketones is described. Mechanistic experiments demonstrate that the different allene enantiomers react in parallel to either the diastereomeric E- or Z-allylic 1,3-diketones with the same absolute configuration of the newly formed stereogenic center. A broad substrate scope demonstrates the synthetic utility of this new method.

Composition for preventing hair loss and promting hair growth containing red ginseng oil

The present invention relates to prevention of hair loss and promotion of hair growth of red ginseng oil and/or a red ginseng extract. When the composition of the present invention is subject to an oral administration and/or transdermal topical application method, a remarkable hair growth effect is exhibited in general hair loss, and a remarkable therapeutic effect against androgenic hair loss is exhibited. Therefore, the red ginseng oil and/or the red ginseng extract can be used as a pharmaceutical composition for preventing or treating hair loss, and as a cosmetic composition for preventing hair loss and promoting hair growth.COPYRIGHT KIPO 2018

A three-carbon (n+1+2) ring expansion method for the synthesis of macrocyclic enones. Application to muscone synthesis

The three-carbon ring expansion methodology commences with the preparation of a cyclic allene (C9, C11, C13), readily available from the corresponding cycloalkene via dibromocarbene addition and subsequent treatment with methyllithium. Dichloroketene addition to the cyclic allene regioselectively provides the [2+2] cycloadduct, which is reductively dechlorinated with zinc in methanol. The resulting cyclobutanone is then catalytically hydrogenated; cyclobutanone ring opening is affected with trimethylsilyl iodide; immediate dehydroiodination of the resulting β-iodocycloalkanone with diazabicycloundecane (DBU) provides the corresponding macrocyclic enone. The 15-membered enone was converted to d,l-muscone with (CH3)2CuLi.