56017-36-8Relevant articles and documents
Copper-Mediated Remote C-H Bond Chalcogenation of Quinolines on the C5 Position
Zhu, Longzhi,Qiu, Renhua,Cao, Xin,Xiao, Song,Xu, Xinhua,Au, Chak-Tong,Yin, Shuang-Feng
, p. 5528 - 5531 (2015)
An efficient and convenient method is developed for the remote C-H bond chalcogenation of 8-aminoquinoline scaffolds on the C5 position that is geometrically inaccessible. The protocol makes use of inexpensive CuBr2 as mediator and shows good t
Copper-Catalyzed C5-H Sulfenylation of Unprotected 8-Aminoquinolines Using Sulfonyl Hydrazides
Yu, Qing,Yang, Yiming,Wan, Jie-Ping,Liu, Yunyun
, p. 11385 - 11391 (2018)
The synthesis of C5-sulfenylated 8-aminoquinolines using unprotected 8-aminoquinolines and sulfonyl hydrazides is achieved via the catalysis of CuI. The reactions are hypothesized to proceed via the Cu(I)-Cu(II)-Cu(I) catalytic processes induced by aerobic oxidation and single-electron transfer on the Cu(II)-8-aminoquinoline complex. This work discloses an unprecedented step-efficient method for the synthesis of C5-sulfenylated 8-aminoquinolines bearing a useful free NH2 group.