56035-75-7Relevant academic research and scientific papers
Reactivity of the pyrimidine nitrogen atom toward an acetal moiety: Formation of 3-ethoxy-2,3-dihydroimidazo[1,2-c ]pyrimidines by intramolecular cyclization of n -(2,2-diethoxyethyl)pyrimidine-4-amines
Juskenas, Robertas,Masevicius, Viktoras,Tumkevicius, Sigitas
, p. 2438 - 2446 (2013)
A new protocol was developed for the synthesis of 2,3-dihydroimidazo[1,2-c] pyrimidines, based on an intramolecular reaction between a pyrimidine nitrogen atom and an acetal moiety in the presence of boron trifluoride etherate. The method was expanded to permit the synthesis of the triheterocyclic imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine system.
