56052-26-7

Basic information

• Product Name: (1-BROMONAPHTHALEN-4-YL)METHANOL
• Synonyms: (4-BROMO-NAPHTHALEN-1-YL)-METHANOL;(1-BROMONAPHTHALEN-4-YL)METHANOL;1-Bromo-4-hydroxymethylnaphthalene
• CAS NO: 56052-26-7
• Molecular Formula: C₁₁H₉BrO
• Molecular Weight: 237.09
• Mol File: 56052-26-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: (1-BROMONAPHTHALEN-4-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1-BROMONAPHTHALEN-4-YL)METHANOL(56052-26-7)
• EPA Substance Registry System: (1-BROMONAPHTHALEN-4-YL)METHANOL(56052-26-7)

Safety Data

• Hazardous Substances Data: 56052-26-7(Hazardous Substances Data)

Usage

Description

(1-BROMONAPHTHALEN-4-YL)METHANOL, with the molecular formula C11H9BrO, is a chemical compound derived from naphthalene. It features a bromine atom and a hydroxyl group, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and dyes. Its applications in research and development as a reagent in organic synthesis highlight its significance in the field of organic chemistry and drug development. However, it is known to have moderate toxicity, necessitating careful handling in laboratory settings.

Uses

Used in Pharmaceutical Industry:
(1-BROMONAPHTHALEN-4-YL)METHANOL is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, (1-BROMONAPHTHALEN-4-YL)METHANOL is utilized as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Dye Industry:
(1-BROMONAPHTHALEN-4-YL)METHANOL is employed as a building block in the synthesis of dyes, contributing to the development of novel colorants for various applications, including textiles and printing inks.
Used in Research and Development:
As a reagent in organic synthesis, (1-BROMONAPHTHALEN-4-YL)METHANOL is used in research and development to explore new chemical reactions and pathways, potentially leading to the discovery of innovative compounds and materials.

Upstream product

• 79996-99-9 1-bromo-4-bromomethyl-naphthalene 
• 46258-62-2 1-(4-bromonaphthalen-1-yl)ethanone 
• 444913-42-2 (4-bromo-1-naphthyl)methyl acetate 
• 16650-55-8 4-bromonaphthalene-1-carboxylic acid 
• 90-11-9 1-Bromonaphthalene 

Downstream Products

• 1093281-19-6 (4-(4-methoxyphenyl)naphthalen-1-yl)methanol 
• 1425052-07-8 C₃₂H₄₄BNO₆Si 
• 1425051-93-9 C₂₆H₃₀BNO₆ 
• 1425051-95-1 C₃₃H₃₄BN₃O₉ 
• 1425052-09-0 C₄₄H₅₃BN₂O₈Si 
• 1425051-97-3 C₃₈H₃₉BN₂O₈ 
• 1425051-98-4 C₄₅H₄₃BN₄O₁₁ 
• 50672-84-9 4-bromo-1-naphthaldehyde 
• 1125812-60-3 methyl 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]naphthalene-1-carboxylate 
• 16650-55-8 4-bromonaphthalene-1-carboxylic acid 
• 41014-20-4 4-bromomethyl-1-naphthonitrile 
• 79996-99-9 1-bromo-4-bromomethyl-naphthalene 

Relevant articles and documents

Pd-catalyzed allylative dearomatisation using Grignard reagents

Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.

ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS

The present invention relates to novel and inventive isoxazoline of formula (I) and salts thereof: wherein variables D1, D2, D3, D4, D5, R1, B1, B2, B3, R2, R3, R4, R5, R6, Y, Z, L, a and b are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

CYP17 inhibitors. Annulations of additional rings in methylene imidazole substituted biphenyls: Synthesis, biological evaluation and molecular modelling

Twenty-one novel compounds originating from two classes of annulated biphenyls were synthesized as mimetics of the steroidal A- and C-rings and examined for their potency as inhibitors of human CYP17. Selected compounds were tested for inhibition of the hepatic CYP enzyme 3A4. Potent CYP17 inhibitors were found for each class, compound 9 (17 and 71% at 0.2 and 2 μM, respectively) and 21 (591 nM). Compound 21 showed only weak inhibition of CYP3A4 (32 and 64% at 2 and 10 μM, respectively). Both compounds, however, exhibited moderate to strong inhibition of the glucocorticoid-forming enzyme CYP11B1. The most interesting compounds were docked into our protein model. They bound into one of the modes which we have previously published. New interaction regions were identified.