56052-50-7

Basic information

• Product Name: 2-(Phenylmethoxy)benzenepropionic acid methyl ester
• Synonyms: 2-(Phenylmethoxy)benzenepropionic acid methyl ester
• CAS NO: 56052-50-7
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.32
• Mol File: 56052-50-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Phenylmethoxy)benzenepropionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Phenylmethoxy)benzenepropionic acid methyl ester(56052-50-7)
• EPA Substance Registry System: 2-(Phenylmethoxy)benzenepropionic acid methyl ester(56052-50-7)

Safety Data

• Hazardous Substances Data: 56052-50-7(Hazardous Substances Data)

Upstream product

• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 20349-89-7 methyl 3-(2-hydroxyphenyl)propionate 
• 100-44-7 benzyl chloride 
• 1300740-57-1 methyl 2-[2-(benzyloxy)benzyl]-3-oxo-3-phenylpropanoate 
• 1300740-56-0 C₁₇H₁₆N₂O₃ 
• 100-39-0 benzyl bromide 

Downstream Products

• 1300740-57-1 methyl 2-[2-(benzyloxy)benzyl]-3-oxo-3-phenylpropanoate 
• 1300740-56-0 C₁₇H₁₆N₂O₃ 
• 129410-07-7 trans-methyl 4-oxo-2-phenylchromane-3-carboxylate 
• 487-26-3 Flavanone 
• 445290-49-3 1,6-dimethyl-2-[3-(2-benzyloxyphenyl)-propanamido]methyl-3-benzyloxy-4(1H)-pyridinone 
• 445290-40-4 N-[2-(2-benzyloxyphenyl)-ethylcarboxy]succinimide 
• 48179-00-6 3-(2'-(Benzyloxy)phenyl)propionic Acid 

Relevant articles and documents

Solvent influence in the Rh-catalyzed intramolecular 1,6 C-H insertions: A general approach to the chromane and flavanone skeletons

Solvent polarity and nature of the ligands on the catalyst are crucial factors that control the regioselectivity of the Rh(II) promoted intramolecular 1,6 C-H insertions versus the β-elimination. We have explored the best conditions for the preparation of flavanones and chromenes through this approach. The procedure is also an excellent way of preparing stereochemically pure Z aryl-alkenes.

Novel Compounds

There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.

Synthesis and physicochemical assessment of novel 2-substituted 3-hydroxypyridin-4-ones, novel iron chelators

Novel 3-hydroxypyridin-4-one containing tridentate ligands were synthesised and their physicochemical properties characterised, including ionisation constants and stoichiometric titration with Fe(III). There is an urgent demand for orally active iron chelators with potential for the treatment of thalassaemia. In principle, tridentate ligands are likely to be more kinetically stable than bidentate molecules, but to date no satisfactory molecules have been identified. Fe(III) stability constants were assessed by competition with the hexadentate ligand EDTA. In all cases no evidence was found for a tridentate mode of iron chelation; instead the ligands behaved as bidentate hydroxypyridinones. As a consequence they provide no advantage over the more simple alkyl hydroxypyridinones.

Endothelin antagonists

A compound of formula (I), in which: R1is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2is hydrogen, hydroxy or protected h