5606-41-7Relevant articles and documents
Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks
Li, Liping,Gao, Hui,Sun, Ming,Zhou, Zhi,Yi, Wei
supporting information, p. 5473 - 5478 (2020/07/14)
Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.
Synthesis of highly branched oligoethylenes by air-stable N,N-indazole derivate methallyl Ni(II) complexes
Araya, Claudia,Correa, Sebastián A.,Daniliuc, Constantin G.,Martínez-díaz, Iván,Rojas, René S.
, (2020/05/19)
Two new neutral N,N-indazole ligands bearing the carbonitrile functional group (L1 and L2) and two new air-stable cationic nickel methallyl complexes (C1 and C2) were prepared. These compounds were fully characterized by NMR, FT-IR and elemental analysis.
Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines
Hu, Kun,Zhen, Qianqian,Gong, Julin,Cheng, Tianxing,Qi, Linjun,Shao, Yinlin,Chen, Jiuxi
supporting information, p. 3083 - 3087 (2018/05/28)
The first example of the palladium-catalyzed, three-component tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids has been developed, providing a new approach for one-pot assembly of diverse quinazolines in moderate to good yields. A noteworthy feature of this method is the tolerance of bromo and iodo groups, which affords versatility for further synthetic manipulations. Preliminary mechanistic experiments indicate that this tandem process involves two possible mechanistic pathways for the formation of quinazolines via catalytic carbopalladation of the cyano group.
A Synthesis of 1H-Indazoles via a Cu(OAc)2-Catalyzed N-N Bond Formation
Chen, Cheng-Yi,Tang, Guangrong,He, Fengxian,Wang, Zhaobin,Jing, Hailin,Faessler, Roger
supporting information, p. 1690 - 1693 (2016/04/26)
A facile synthesis of 1H-indazoles featuring a Cu(OAc)2-catalyzed N-N bond formation using oxygen as the terminal oxidant is described. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to o-aminoar
Efficient and scalable synthesis of ketones via nucleophilic Grignard addition to nitriles using continuous flow chemistry
Mateos, Carlos,Rincón, Juan A.,Villanueva, José
supporting information, p. 2226 - 2230 (2013/05/08)
In the present Letter we report the development of efficient continuous flow chemistry conditions for the scalable preparation of ketones. This transformation is achieved via nucleophilic addition of Grignard reagents to the corresponding nitriles and imine hydrolysis by means of in-series plug flow reactors.
Ring forming reactions of imines of 2-aminobenzaldehyde and related compounds
Wiklund, Per,Bergman, Jan
, p. 367 - 372 (2007/10/03)
By addition of organometallic reagents to 2-aminobenzonitriles followed by quenching with suitable electrophiles (acyl halides, aldehydes and ketones), several types of 6-membered benzofused aromatic and non-aromatic nitrogen heterocycles could be obtained. Rearrangements leading to 1,2-dihydro-3H-1,4-benzodiazepin-3-ones and preparation of various quinazolines are described.
Intermediates for preparing 1,4-benzodiazepine-2-ones having a carboxylic acid ester or amide group in the 3-position
-
, (2008/06/13)
Intermediates for preparing novel benzodiazepines having the formula SPC1 In which R1 is a hydrogen or halogen atom or a trifluoromethyl, loweralkyl, loweralkoxy, nitro or amino group; R2 is a furyl, a thienyl, cyclohexyl, a loweralkyl group or a phenyl group which may be substituted by a halogen atom or by a trifluoromethyl, nitro, loweralkoxy or loweralkyl group; and R3 is a hydrogen atom or a loweralkyl group; and R4 is lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)carbamoyl, a group having the formula --COOCat in which Cat is a cation of an alkali metal or a semication of an alkaline earth metal or COOCat.CatOH, said intermediates being ortho-aminoaryl ketimines having the formula SPC2 Wherein R is hydrogen or EQU1 R1, R2, and R3 are as defined above, R4 is a hydrogen atom, a lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)-carbamoyl, alkyl or substituted alkyl group; and R5 is a loweralkyl group.
