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Upstream product

• 3460-11-5 4-nitrobenzanilide 
• 100-47-0 benzonitrile 
• 2585-26-4 4-nitro-N-benzylbenzamide 
• 99-99-0 1-methyl-4-nitrobenzene 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 104-03-0 4-nitrobenzeneacetic acid 
• 98-80-6 phenylboronic acid 
• 1885-29-6 anthranilic acid nitrile 
• 153172-75-9 N-(2-cyanophenyl)-4-nitrobenzamide 
• 555-16-8 4-nitrobenzaldehdye 
• 5606-41-7 2-(imino(phenyl)methyl)aniline 
• 5466-94-4 4-Nitro-N-phenyl-benzimidoyl chloride 
• 1609460-30-1 N-benzyl-4-nitro-N'-phenylbenzimidamide 
• 3712-57-0 N-benzyl-4-nitrobenzimidoyl chloride 

Relevant academic research and scientific papers

Mn(OAc) 3Induced C-4 Arylations of Quinazoline 3-Oxides with Arylboronic Acids

The use of manganese triacetate as an oxidant component in the C-4 arylations of 2-aryl-quinazoline 3-oxides with arylboronic acids is reported. The new protocol was applied to prepare new 2,4-diarylated quinazoline 3-oxides in good to high yields. The me

A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions?

A new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditio

TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes usingcat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formedin situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.

Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines

The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, ha

Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines

The first example of the palladium-catalyzed, three-component tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids has been developed, providing a new approach for one-pot assembly of diverse quinazolines in moderate to good yields. A noteworthy feature of this method is the tolerance of bromo and iodo groups, which affords versatility for further synthetic manipulations. Preliminary mechanistic experiments indicate that this tandem process involves two possible mechanistic pathways for the formation of quinazolines via catalytic carbopalladation of the cyano group.

Efficient One-Pot Synthesis of Quinazoline and Benzopyrano[2,3-d]pyrimidine Derivatives Catalyzed by N-Bromosulfonamides

N,N,N',N'-tetrabromobenzene-1,3-disulfonamide and poly(N,N’-dibromo-N-ethyl-benzene-1,3-disulfonamide) were used as efficient catalysts for one-pot synthesis of new quinazoline derivatives from various aldehydes, 2-amino-benzophenone, and ammonium acetate

Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: A facile access to 2-arylquinazolines

An efficient copper-catalyzed oxidative decarboxylative amination of arylacetic acids with 2-aminobenzoketones and ammonium acetate under an oxygen atmosphere was first developed. This reaction represents a novel avenue for 2-arylquinazolines in good to e

Potassium iodide-catalyzed three-component synthesis of 2-arylquinazolines via amination of benzylic C-H bonds of methylarenes

A novel potassium iodide-catalyzed three-component synthesis of quinazolines via benzylic C-H bonds amination was developed. Commonly used ammonia salt and the sp3 carbon in commercially available methylarenes were used as nitrogen and C1 sources, respectively. Mechanistic studies indicated that an aryl aldehyde is involved as a key intermediate in the reaction.

Pentafluorophenylammonium triflate as a suitable and effective metal-free catalyst for the synthesis of quinazoline derivatives via one-pot multicomponent method

A simple and facile synthesis of highly functionalized quinazoline derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and 2-aminoaryl ketones or isatoic anhydride under reflux conditions in the presence of a pentafluorophenylammonium triflate (PFPAT) organocatalyst. These catalytic condensation reactions represent green chemical processes, while the PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.

Solvent/oxidant-switchable synthesis of multisubstituted quinazolines and benzimidazoles via metal-free selective oxidative annulation of arylamidines

A fast and simple divergent synthesis of multisubstituted quinazolines and benzimidazoles was developed from readily available amidines, via iodine(III)-promoted oxidative C(sp3)-C(sp2) and C(sp 2)-N bond formation in nonpolar and polar solvents, respectively. Further selective synthesis of quinazolines in polar solvent was realized by TEMPO-catalyzed sp3C-H/sp2C-H direct coupling of the amidine with K2S2O8 as the oxidant. No metal, base, or other additives were needed.