56098-69-2Relevant academic research and scientific papers
α-Lithioamine Synthetic Equivalents: Syntheses of Diastereoisomers from the Boc Piperidines
Beak, Peter,Lee, Won Koo
, p. 2578 - 2580 (2007/10/02)
The α'-lithiations and electrophilic substitutions of selected Boc piperidines provide single or separable diastereoisomeric 2-substituted, 2,4-disubstituted, and 2,4,6-trisubstituted Boc piperidines which are readily hydrolyzed to the substituted piperidines.
STEREOSELECTIVE CONDENSATIONS OF α'-LITHIO PYRROLIDINE AMIDINES
Sanner, Mark A.
, p. 1909 - 1912 (2007/10/02)
The condensation of α'-lithio pyrrolidine amidine 5 with aromatic aldehydes gives hydroxymethyl pyrrolidines 6 with high threo-erythro selectivity (ca. 95:5).In contrast, the analogous reaction with lithiopiperidine amidine 9 is stereorandom.
