561007-47-4Relevant academic research and scientific papers
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity
Grembecka, Jolanta,Mucha, Artur,Cierpicki, Tomasz,Kafarski, Pawe?
, p. 2641 - 2655 (2007/10/03)
A new class of very potent inhibitors of cytosol leucine aminopeptidase (LAP), a member of the metalloprotease family, is described. The X-ray structure of bovine lens leucine aminopeptidase complexed with the phosphonic acid analogue of leucine (LeuP) wa
Hydrolysis of the Phosphonamidate Bond in Phosphono Dipeptide Analogues - The Influence of the Nature of the N-Terminal Functional Group
Mucha, Artur,Grembecka, Jolanta,Cierpicki, Tomasz,Kafarski, Pawel
, p. 4797 - 4803 (2007/10/03)
Phosphonamidate pseudodipeptides, designed as transition state analogue inhibitors of leucine aminopeptidase, revealed unexpected instability in aqueous solutions of pH values varying from acidic up to highly basic. This reaction has been studied in some
