561064-18-4

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-3-(4-methoxybutyl)-
• CAS NO: 561064-18-4
• Molecular Formula: C9H13ClN2O3
• Molecular Weight: 232.667
• Mol File: 561064-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-3-(4-methoxybutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-3-(4-methoxybutyl)-(561064-18-4)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-3-(4-methoxybutyl)-(561064-18-4)

Safety Data

• Hazardous Substances Data: 561064-18-4(Hazardous Substances Data)

Upstream product

• 98385-96-7 N-(4-Methoxybutyl)harnstoff 
• 561064-19-5 1-(4-methoxybutyl)barbituric acid 

Downstream Products

• 496943-52-3 3-{4-[4-(tert-butoxycarbonyl)piperazino-1-yl]butyl}-6-(3-ethyl-4-methylanilino)uracil 
• 561064-42-4 3-(4-azido-butyl)-6-(3-ethyl-4-methyl-phenylamino)-1H-pyrimidine-2,4-dione 
• 561064-32-2 6-[3-(1-hydroxy-ethyl)-4-methyl-phenylamino]-3-(4-methoxy-butyl)-1H-pyrimidine-2,4-dione 
• 478921-51-6 3-(4-aminobutyl)-6-(3-ethyl-4-methylanilino)uracil 
• 561064-25-3 6-(3-chloromethyl-4-methyl-phenylamino)-3-(4-methoxy-butyl)-1H-pyrimidine-2,4-dione 
• 308833-37-6 3-(4-Iodobutyl)-6-(3-ethyl-4-methylanilino)uracil 
• 292619-96-6 HB-EMAU 

Relevant articles and documents

Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and gram-positive bacterial growth

Certain substituted 6-anilinouracils are potent and selective inhibitors of Gram+ bacterial DNA polymerase IIIC (pol IIIC). In addition, analogues with 3-substituents in the uracil ring have potent antibacterial activity against Gram+ organisms in culture. In an attempt to find optimal anilino substituents for pol IIIC binding and optimal 3-substituents for antibacterial activity, we have prepared several series of 3-substituted-6-aminouracils and assayed their activity against pol IIIC from Bacillus subtilis and a panel of Gram+ and Gram- bacteria in culture. The 6-(3-ethyl-4-methylanilino) group and closely related substituent patterns maximized pol IIIC inhibition potency. Among a series of 3-(substituted-butyl)-6-(3-ethyl-4-methylanilino)uracils, basic amino substituents increased pol IIIC inhibition, but decreased antibacterial activity. The most potent antibacterials were simple hydroxybutyl and methoxybutyl derivatives, and hydrophobically substituted piperidinylbutyl derivatives.