496943-52-3

Upstream product

• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 308833-37-6 3-(4-Iodobutyl)-6-(3-ethyl-4-methylanilino)uracil 
• 98385-96-7 N-(4-Methoxybutyl)harnstoff 
• 292619-97-7 3-(4-methoxybutyl)-6-(3-ethyl-4-methylanilino)uracil 
• 561064-18-4 6-chloro-3-(4-methoxybutyl)uracil 
• 561064-19-5 1-(4-methoxybutyl)barbituric acid 

Relevant academic research and scientific papers

Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and gram-positive bacterial growth

Certain substituted 6-anilinouracils are potent and selective inhibitors of Gram+ bacterial DNA polymerase IIIC (pol IIIC). In addition, analogues with 3-substituents in the uracil ring have potent antibacterial activity against Gram+ organisms in culture. In an attempt to find optimal anilino substituents for pol IIIC binding and optimal 3-substituents for antibacterial activity, we have prepared several series of 3-substituted-6-aminouracils and assayed their activity against pol IIIC from Bacillus subtilis and a panel of Gram+ and Gram- bacteria in culture. The 6-(3-ethyl-4-methylanilino) group and closely related substituent patterns maximized pol IIIC inhibition potency. Among a series of 3-(substituted-butyl)-6-(3-ethyl-4-methylanilino)uracils, basic amino substituents increased pol IIIC inhibition, but decreased antibacterial activity. The most potent antibacterials were simple hydroxybutyl and methoxybutyl derivatives, and hydrophobically substituted piperidinylbutyl derivatives.

N3-substituted 6-anilinopyrimidines and methods to treat-Gram-positive bacterial and mycoplasmal infections

Compounds useful for treating Gram-positive bacterial and mycoplasmal infections are disclosed. The compounds have the general formulae shown below.