561302-52-1

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 161315-55-5 3-[2-(N-t-BOC-4-piperidinyl)-1-oxoethyl]-4(R)-(benzyl)-2-oxazolidinone 
• 157688-46-5 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 

Downstream Products

• 561302-80-5 (2S,3R)-3-(3-Hydroxy-benzyl)-N-((1S,2R)-2-hydroxy-indan-1-yl)-2-(1-methyl-piperidin-4-yl)-succinamic acid 
• 561302-62-3 2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 1-tert-butyl ester 
• 561302-70-3 2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-benzyl ester 
• 561302-65-6 2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-benzyl ester 1-tert-butyl ester 
• 561302-72-5 4-[(S)-1-Carboxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-(3-hydroxy-phenyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 561302-73-6 4-[(1S,2R)-1-Hydroxycarbamoyl-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-(3-hydroxy-phenyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 561302-76-9 (2S,3R)-3-(3-Benzyloxy-benzyl)-N-((1S,2R)-2-hydroxy-indan-1-yl)-2-piperidin-4-yl-succinamic acid benzyl ester 
• 561302-78-1 (2S,3R)-3-(3-Benzyloxy-benzyl)-N-((1S,2R)-2-hydroxy-indan-1-yl)-2-(1-methyl-piperidin-4-yl)-succinamic acid benzyl ester 
• 561302-71-4 4-[(S)-1-Benzyloxycarbonyl-3-(3-benzyloxy-phenyl)-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Anti-succinate hydroxamates with cyclic P1 motifs were synthesized as aggrecanase inhibitors. The N-methanesulfonyl piperidine 23 and the N-trifluoroacetyl azetidine 26 were the most potent aggrecanase inhibitors both having an IC50=3 nM while