561302-72-5

Upstream product

• 561302-65-6 2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-benzyl ester 1-tert-butyl ester 
• 561302-70-3 2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-benzyl ester 
• 561302-62-3 2-(3-benzyloxy-benzyl)-3-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 1-tert-butyl ester 
• 561302-52-1 4-[2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-tert-butoxycarbonylmethyl-2-oxo-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 161315-55-5 3-[2-(N-t-BOC-4-piperidinyl)-1-oxoethyl]-4(R)-(benzyl)-2-oxazolidinone 
• 561302-56-5 2-(1-tert-butoxycarbonyl-piperidin-4-yl)-succinic acid 4-tert-butyl ester 
• 157688-46-5 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 
• 96995-06-1 1-(benzyloxy)-3-(iodomethyl)benzene 
• 561302-71-4 4-[(S)-1-Benzyloxycarbonyl-3-(3-benzyloxy-phenyl)-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 561302-73-6 4-[(1S,2R)-1-Hydroxycarbamoyl-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-(3-hydroxy-phenyl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents

Anti-succinate hydroxamates with cyclic P1 motifs were synthesized as aggrecanase inhibitors. The N-methanesulfonyl piperidine 23 and the N-trifluoroacetyl azetidine 26 were the most potent aggrecanase inhibitors both having an IC50=3 nM while