5616-30-8

Usage

Uses

Used in Pharmaceutical Industry:
(4-AMINO-BENZENESULFONYLAMINO)-ACETIC ACID is used as a building block for the synthesis of sulfonamide drugs, which are a class of antimicrobial agents. These drugs are effective against a wide range of bacterial infections and are commonly used in the treatment of urinary tract infections, respiratory infections, and other bacterial diseases.
Used in Chemical Research:
In the field of chemical research, (4-AMINO-BENZENESULFONYLAMINO)-ACETIC ACID is used as a reagent for various chemical reactions. Its unique chemical structure allows it to participate in a range of reactions, such as substitution, condensation, and rearrangement reactions, making it a valuable tool for the synthesis of complex organic compounds.
Used in Immunoassays:
(4-AMINO-BENZENESULFONYLAMINO)-ACETIC ACID is used as a detection agent in immunoassays for the detection of sulfonamide drugs. These assays are essential in the pharmaceutical industry for quality control and in the medical field for monitoring drug levels in patients receiving sulfonamide treatment. (4-AMINO-BENZENESULFONYLAMINO)-ACETIC ACID's ability to interact with antibodies specific to sulfonamide drugs makes it a reliable indicator for the presence of these drugs in samples.

Upstream product

• 23776-98-9 N-[[4-(Acetylamino)phenyl]sulfonyl]glycine 
• 15054-44-1 2-[(4-nitrobenzene)sulfonamido]acetic acid 
• 24939-24-0 4-aminobenzenesulfonyl chloride 
• 56-40-6 glycine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 109065-72-7 (4-Dimethylamino-benzenesulfonylamino)-acetic acid 
• 109065-79-4 [4-(2-Benzyloxy-acetylamino)-benzenesulfonylamino]-acetic acid 
• 109065-75-0 {4-[(E)-(3-Phenyl-acryloyl)amino]-benzenesulfonylamino}-acetic acid 
• 109065-69-2 BAPSG 
• 109065-76-1 N-phenyl-N'-[4-(N-glycinylsulfonyl)phenyl]urea 
• 109065-78-3 [4-(2-Phenoxy-acetylamino)-benzenesulfonylamino]-acetic acid 
• 99362-95-5 methyl 2-(4-aminophenylsulfonamido)acetate 
• 55578-35-3 N-(N-sulfanilyl-sulfanilyl)-glycine 
• 109065-74-9 N-[[4-[(2-Phenylethyl)carbonylamino]phenyl]sulfonyl]glycine 
• 109065-73-8 N-[[4-(Phenylacetylamino)phenyl]sulfonyl]glycine 
• 58960-90-0 N-[(4-{[(benzyloxy)carbonyl]amino}phenyl)sulfonyl]glycine 
• 109065-77-2 N-phenyl-N'-[4-(N-glycinylsulfonyl)phenyl]thiourea 

Relevant academic research and scientific papers

From a MMP2/CK2 multitarget approach to the identification of potent and selective MMP13 inhibitors

In this article, we describe our efforts in the search of MMP2/CK2 dual targeting inhibitors. We have followed a rational drug design approach based on our experience in the selective inhibition of these two enzymes. We have successfully obtained highly a

Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease

Novel multifunctional 3,6-Diphenyl-1,4-bis(phenylsulfonyl)piperazine-2,5-dione derivatives were designed and synthesized for the treatment of Alzheimer's disease (AD). The designed scaffold has blood brain barrier penetrating ability, acetylcholinesterase (AChE) and matrix metalloproteinase-2 (MMP-2) inhibition potential. Compounds 52 and 46 showed very significant inhibition against AChE, IC50 = 32.45 ± 0.044, 28.65 ± 0.029, BuChE, IC50 = 157.95 ± 0.264, 160.58 ± 0.082 and MMP-2, IC50 = 36.83 ± 0.015, 19.57 ± 0.005 (nM). In the enzyme kinetics study, lead molecule 46 showed non-competitive inhibition of AChE with Ki = 7 nM and competitive inhibition of MMP-2 with Ki = 20 nM. Compounds 52 and 46 inhibited AChE-induced Aβ aggregation at 20 μM. The compounds also exhibited in-vitro antioxidant potential in DPPH assay. Further, compound 46 was found to be a promising neuroprotective agent in MC65 cells. Lead molecule 46 significantly enhanced working memory in scopolamine induced amnesia animal model at dose of 5 mg/kg dose. The mitochondrial membrane potential was restored in animals when treated with compounds 52 and 46.