56160-03-3Relevant academic research and scientific papers
Rational Use of Heterogeneous Data in Quantitative Structure-Activity Relationship (QSAR) Modeling of Cyclooxygenase/Lipoxygenase Inhibitors
Lagunin, Alexey A.,Geronikaki, Athina,Eleftheriou, Phaedra,Pogodin, Pavel V.,Zakharov, Alexey V.
, (2019/03/02)
Numerous studies have been published in recent years with acceptable quantitative structure-activity relationship (QSAR) modeling based on heterogeneous data. In many cases, the training sets for QSAR modeling were constructed from compounds tested by dif
Analgesic and antiinflammatory activity of derivatives of 2-aminobenzothiazole
Deodhar, Meenakshi N.,Dongre, Ashishkumar C.,Kudale, Sayali D.
, p. 2747 - 2752 (2012/09/22)
A series of 5-(4-substituted benzylidene-2-(substituted benzo[d]thiazol-2-ylimino)thiazolidin-4-one (5a-r) have been synthesized from 2-aminobenzothiazole as starting material. Condensation of thiazolidin-4-one with different substituted aromatic benzaldehyde occurred at reactive methylene group present at C-5 position of thiazolidin-4-one ring and resulted in the formation of compounds (5a-r). These were characterized using physical and spectral methods. The compounds (5a-r) were evaluated for analgesic and antiinflammatory activity using in vivo models.
2-thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action
Geronikaki,Eleftheriou,Vicini,Alam,Dixit,Saxena
experimental part, p. 5221 - 5228 (2009/07/01)
SHP-2, a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene, mediates cell signaling by growth factors and cytokines via the RAS/MAP kinase pathway. Somatic mutations in PTPN11 gene account for approximately 18% of juvenile myelomonocytic
