5618-62-2

Usage

Uses

Used in Pharmaceutical Industry:
O-(2-Methylpropyl)hydroxylamine is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of drugs that target specific biological pathways or receptors, contributing to the development of new therapeutic agents.
Used in Pesticide Industry:
In the pesticide industry, O-(2-Methylpropyl)hydroxylamine serves as an intermediate in the synthesis of certain pesticides. Its reactivity and functional group make it suitable for creating compounds that can effectively control, repel, or kill pests, thereby enhancing crop protection and yield.
Used in Organic Chemistry:
O-(2-Methylpropyl)hydroxylamine is utilized in organic chemistry as a reagent or building block for the synthesis of a wide range of organic compounds. Its versatility in reactions allows chemists to create diverse molecules with potential applications in various fields, such as materials science, fragrances, and dyes.
Used in Research and Development:
O-(2-Methylpropyl)hydroxylamine is also employed in research and development settings, where it can be used to explore new chemical reactions, investigate the properties of hydroxylamines, or develop novel synthetic methodologies. Its presence in the lab enables scientists to push the boundaries of chemical knowledge and innovation.

InChI:InChI=1/C4H11NO/c1-4(2)3-6-5/h4H,3,5H2,1-2H3

Upstream product

• 13259-29-5 sodium isobutoxide 
• 18498-63-0 N-isobutoxy-acetimidic acid ethyl ester 
• 63767-49-7 isobutoxycarbamic acid ethyl ester 
• 52026-51-4 O-1-(2-methyl)propyl-N-hydroxyphthalimide 
• 513-38-2 Isobutyl iodide 
• 589-41-3 ethyl N-hydroxylcarbamate 

Downstream Products

• 219778-40-2 5-bromo-3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-N-isobutoxy-benzamide 
• 6084-58-8 O-isobutylhydroxylamine hydrochloride 
• 55634-73-6 2-(1-Isobutoxyamino-propylidene)-5,5-dimethyl-cyclohexane-1,3-dione 

Relevant academic research and scientific papers

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been identified as potent MEK inhibitors. 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzam ide, CI-1040, was the first MEK inhibitor to demonstrate in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI-1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated. Optimization of the diphenylamine core and modification of the hydroxamate side chain for cell potency, solubility, and exposure with oral delivery resulted in the discovery of the clinical candidate N-(2,3-dihydroxy-propoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-b enzamide PD 0325901.

Synthesis and fungicidal activity of macrolactams and macrolactones with an oxime ether side chain

Three series of novel macrolactams and macrolactones - 12-alkoxyimino- tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by 1H NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by 1H NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuehn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.

Nodulisporic acid derivatives

The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.