56208-05-0

Usage

Physical state

Colorless liquid

Odor

Slightly fruity

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Additional use

Solvent in various industrial processes

Hazard classification

Classified as a hazardous substance

Potential health risks

Causes skin and eye irritation, harmful if swallowed or inhaled

Safety measures

Proper handling procedures and precautions should be followed to minimize risks to human health and the environment

Upstream product

• 105-33-9 4-chloro-3-hydroxybutyronitrile 
• 79-03-8 propionyl chloride 

Relevant academic research and scientific papers

Preparation of (R)- and (S)-4-chloro-3-acetoxybutyronitrile using microbial resolution

A new preparation of optically active 4-chloro-3-acetoxybutyronitrile (AcBN) was developed using the resting cells of bacteria. The resolution was based on enantioselective hydrolysis of the ester function of the substrate. (R)-AcBN was prepared using Pseudomonas sp. DS-K-717, and the resulting (R)-AcBN was obtained with high enantiomeric excess of >98% with a yield of 36% during the microbial resolution step. (S)-AcBN was prepared in the same manner using the resting cells of Pseudomonas sp. DS-K-19 and showed a high enantiomeric excess of >98% with a yield of 32%. The enzyme activity was enhanced and induced by the addition of AcBN, particularly the (R)-ester hydrolysis, which was enhanced 20-fold.