56218-62-3

Upstream product

• 1080-44-0 N-Tosylglycine 
• 98-59-9 p-toluenesulfonyl chloride 
• 114004-56-7 1,1-Bis--dimethylaether> 

Downstream Products

• 101399-34-2 N-[N-(toluene-4-sulfonyl)-glycyl]-serine methyl ester 
• 4127-97-3 2-amino-3-{[N-(toluene-4-sulfonyl)-glycyl]-amino}-propionic acid 
• 103640-05-7 N-(toluene-4-sulfonyl)-glycine dimethylamide 
• 2478-44-6 2-[[(4-methylphenyl)sulfonyl]amino]-N-phenylacetamide 
• 2478-45-7 Tos-Gly-Gly-OEt 
• 95021-64-0 1,4-bis[(4-methylphenyl)sulfonyl]tetrahydropyrazine-2,5-dione 
• 100723-71-5 Tos-Gly-Pro-OH 
• 100876-85-5 Tosylglycyl-α-methylalanin-methylester 
• 3842-37-3 N^α--N^β--hydrazinoessigsaeure-ethylester 
• 4143-99-1 N^α-Tosyl-N^δ-tosylglycyl-L-ornithin 
• 4127-85-9 N^α-Tosyl-N^γ-tosylglycyl-L-α,γ-diamino-buttersaeure 
• 4143-98-0 N^δ-Tosyl-N^α-tosylglycyl-L-ornithin 
• 5373-25-1 N-(toluene-4-sulfonyl)-glycine cyclohexylamide 
• 90303-08-5 N-Pyridin-4-yl-2-(toluene-4-sulfonylamino)-acetamide 

Relevant academic research and scientific papers

New lactam-containing benzenesulfonamides: design, synthesis, and in silico and in vitro studies

A virtual set of new lactam-containing derivatives of arylsulfonylglycines 1a–d and 2a–d was designed and analyzed using structure–activity computer models (web-services PASS Online, AntiBac-Pred, and GUSAR Acutetoxicity). The antimicrobial activity again

Iodine-Catalyzed Synthesis of Chiral 4-Imidazolidinones Using α-Amino Acid Derivatives via Dehydrogenative N-H/C(sp3)-H Coupling

An efficient method for the asymmetric synthesis of 4-imidazolidinones via an iodine-catalyzed intramolecular N-H/C(sp3)-H activation of readily available and abundant feedstocks, amino acids, and amines is described. The reaction proceeded under visible light irradiation to afford a variety of 4-imidazolidinone derivatives under mild conditions in moderate to excellent yields. Secondary and tertiary C(sp3)-H bonds were aminated, and various functional groups were tolerated.

Metal-Free N–H/C–H Coupling for Efficient Asymmetric Synthesis of Chiral Dihydroquinoxalinones from Readily Available α-Amino Acids

We have developed a method for the synthesis of dihydroquinoxalinones via intramolecular N–H/C–H coupling using hypervalent iodine. The starting materials were prepared from inexpensive and readily available aniline and amino acid derivatives. Various functional groups were tolerated to give multisubstituted dihydroquinoxalinones in moderate to excellent yields. The chirality of the amino acid was transferred to the desired target compound without a loss of enantiomeric excess. Preliminary mechanistic studies indicated that the reaction proceeds via an ionic mechanism.

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. (Chemical Equation Presented).

SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY

The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growthinvitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents.

Synthesis and structural studies of new N-(p-toluenesulfonyl)amino acid o-phenolamides

The synthesis and structural studies of N-(p-Toluenesulfonyl)amino acid o-phenolamides was discussed. The structure and conformation of these amides were established by NMR spectroscopy and x-ray crystallography. Variable temperature experiments showed th

Wolff rearrangement of diazo ketones derived from N-p-tolylsulfonyl-protected α- and β-amino acids

Diazo ketones derived from N-p-tolylsulfonyl (tosyl)-protected α- and β-amino acids have been synthesized and their diazo decomposition under standard Wolff rearrangement conditions, PhCO2Ag-Et3N-MeOH, has been investigated. It is observed that, under these conditions, several different reaction pathways, including direct carbene N-H insertion, are possible. The reaction is markedly affected by the N-protecting group, the substrate structure and solvent. For those diazo ketones derived from N-tosyl-protected β-amino acids, the diazo decomposition with anhydrous THF as solvent and PhCO2Ag dissolved in Et3N as catalyst gives the corresponding 5-substituted pyrrolidinones in excellent yields.