562812-34-4Relevant articles and documents
Au-catalyzed intramolecular hydroalkoxylation of gem-difluorinated alkynols
Hamel, Jean-Denys,Paquin, Jean-Fran?ois
, p. 11 - 23 (2018/10/20)
The intramolecular hydroalkoxylation of gem-difluorinated alkynols was found possible under Au catalysis, allowing for the preparation of a series of fluorinated heterocycles. The nature of the solvent was found to be especially critical in the cyclizatio
A novel approach of cycloaddition of difluorocarbene to α-β-unsaturated aldehydes and ketones: Synthesis of gem-difluorocyclopropyl ketones and 2-fluorofurans
Xu, Wei,Chen, Qing-Yun
, p. 1151 - 1156 (2007/10/03)
A series of gem-difluorocyclopropyl acetals and ketals are easily obtained in moderate yields from the [1 + 2] cycloaddition of difluorocarbene to 1,3-dioxolanes of α,β-unsaturated aromatic aldehydes and ketones. Hydrolysis of these fluorinated compounds under acidic conditions either gives the corresponding gem-difluorocyclopropyl ketones or 1-aryl-2-fluorofuran derivatives through intramolecular carbonium rearrangement with simultaneous ring cleavage.
