60168-63-0Relevant academic research and scientific papers
Au-catalyzed intramolecular hydroalkoxylation of gem-difluorinated alkynols
Hamel, Jean-Denys,Paquin, Jean-Fran?ois
, p. 11 - 23 (2018/10/20)
The intramolecular hydroalkoxylation of gem-difluorinated alkynols was found possible under Au catalysis, allowing for the preparation of a series of fluorinated heterocycles. The nature of the solvent was found to be especially critical in the cyclizatio
PYRIMIDONE DERIVATIVES USED AS TAU PROTEIN KINASE 1 INHIBITORS
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Page/Page column 43, (2011/02/24)
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C-X; X represents hydrogen atom or fluorine atom; R1 is hydrogen atom or a C1 -C3 alkyl group; L represents single bond or a C1 -C6 alkylene group which may be substituted; Y represents single bond, sulfur atom, oxygen atom, NH, or the like; R2 represents hydrogen atom or a cyclic group which may be substituted, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
Acid-catalyzed solvolysis of polyenol ethers. III. Effect of the alkoxy moiety
Nieuwenhuis, Saskia A. M.,Vertegaal, Louis B. J.,De Zoete, Marian C.,Van Der Gen, Arne
, p. 13207 - 13230 (2007/10/02)
The dependence of the solvolysis of polyenol ethers on the nature of the alkoxy moiety has been studied. A new reaction path, leading to the formation of ω-hydroxy (methoxy) substituted aldehydes and -esters, was established. The proposed reaction pathway (scheme 6) is initiated by an electron transfer from the polyenol ether to molecular oxygen, followed by combination of the two radicals to a peroxide zwitterion. Upon protonation, solvent adds to the ω-carbon atom of the polyene to give an intermediate that can either loose water to form an ester, or loose the alkoxy moiety to give an aldehyde. This mechanism is believed to be involved in the strong mutagenic activity displayed by many polyenol ethers, including the natural mutagen fecapentaene-12.
Recognition by New Symmetrically Substituted Chiral Diphenyl- and Di-tert-butylpyridino-18-crown-6 and Asymmetrically Substituted Chiral Dimethylpyridino-18-crown-6 Ligands of the Enantiomers of Various Organic Ammonium Perchlorates
Huszthy, Peter,Bradshaw, Jerald S.,Zhu, Cheng Y.,Izatt, Reed M.,Lifson, Shneior
, p. 3330 - 3336 (2007/10/02)
Three new chiral pyridino-18-crown-6 ligands have been prepared.These ligands contain either two phenyl, two tert-butyl, or two methyl substituents on chiral macroring carbon atoms.The chiral di-tert-butyl-substituted diester crown analogue was also prepared.The starting chiral di-tert-butyl-substituted tetraethylene glycol needed to prepare the two di-tert-butyl-substituted crowns was obtained from chiral tert-butyl-1,2-ethanediol, which was resolved from its bis(hydrogen phthalate) brucine salt.A high degree of chiral recognition in CD2Cl2 of the enantiomers of ammonium perchlorate (NapEt) was shown by the diphenyl- and di-tert-butyl-substituted crowns as measured by differences in the free energy of avtivation (ΔGc*) values determined by temperature dependent 1H NMR spectroscopy.The diphenyl- and di-tert-butyl-substituted crowns also exhibited high chiral recognition for the enantiomers of NapEt and other chiral organic ammonium salts in methanol and methanol-chloroform mixtures as shown by a large difference in the log K values determined by a direct 1H NMR technique.
Asymmetric Radical Reaction in the Coordination Sphere. 2. Asymmetric Addition of Alkane- and Arenesulfonyl Chlorides to Olefins Catalyzed by a Ruthenium(II)-Phosphine Complex with Chiral Ligands
Kameyama, Masayuki,Kamigata, Nobumasa,Kobayashi, Michio
, p. 3312 - 3316 (2007/10/02)
The addition of arenesulfonyl chlorides to styrene in the presence of a catalytic amount of a ruthenium(II) complex with chiral phosphine ligands, Ru2Cl43 or Ru2Cl43, proceeds under mild conditions to give optically active 1:1 adducts,
The Preparation of New Chiral Diphenyl-Substituted Macrocyclic Polyether-Diester Compounds and their Enantiomeric Recognition of Chiral Organic Ammonium Salts
Bradshaw, Jerald S.,Thompson, Patricia K.,Izatt, Reed M.,Morin, Frederick G.,Grant, David M.
, p. 897 - 901 (2007/10/02)
A series of chiral diphenyl-substituted macrocyclic polyether-diester ligands have been prepared from the chiral diphenyl-substituted tetraethylene glycol.Enantiomeric recognition by the chiral diphenyl-sunstituted pyridino-diester-18-crown-6 compound (7)
CLEAVAGE OF METHYLTHIOMETHYL ETHERS BY ELECTROLYTIC PROCEDURE
Mandai, Tadakatsu,Yasunaga, Hiroyasu,Kawada, Mikio,Otera, Junzo
, p. 715 - 716 (2007/10/02)
An electrolytic method for deblocking a methylthiomethyl group is newly developed.
