56300-87-9

Upstream product

• 127180-76-1 ethyl 4-methylcyclohexylideneacetate 
• 77842-31-0 (4-methylcyclohexylidene)acetic acid 
• 5108-88-3 ethyl (1-hydroxy-4-methylcyclohexyl)acetate 
• 589-92-4 1-methylcyclohexan-4-one 
• 486427-89-8 (-)-1-isopropyl-2-methylpropyl (4-phenylcyclohexylidene)acetate 

Downstream Products

• 7071-18-3 2-(4-methylcyclohexylidene)acetaldehyde 

Relevant academic research and scientific papers

External chiral ligand-mediated enantioselective peterson reaction of α-trimethylsilanylacetate with substituted cyclohexanones

(equationpresented) The asymmetric Peterson reaction of an α-trimethylsilanylacetate with 4-substituted and 3,5-disubstituted cyclohexanones was mediated by an external chiral tridentate ligand to give the corresponding olefins with an axial chirality in

Asymmetric Wittig reaction of chiral arsonium ylides - I. Asymmetric olefination of 4-substituted cyclohexanones

Asymmetric Wittig-type olefination of 4-substituted cyclohexanones with chiral ligand-modified stable arsonium ylides has been examined. The 8-phenylmenthol-derived chiral arsonium ylide of 4 reacted with prochiral ketones 9a-d at -15°C to give the 4-substituted cyclohexylideneacetates 11a-d in 58-69% yield and in up to 80% diastereomeric excess (de).

The asymmetric Horner-Emmons reaction using a benzopyrano-isoxazolidine auxiliary

The asymmetric Horner-Emmons reaction of the phosphonate derived from a chiral benzopyrano-isoxazolidine (with 4-substituted cyclohexanones) proceeded in high diastereoselectivity with the aid of KHMDS and 18-crown-6 ether. Enantiomerically pure, axially dissymmetric cyclohexylidene alcohols, aldehydes and ketones were obtained from the diastereomerically pure Horner-Emmons products in a single step.