56326-98-8

Usage

Uses

Used in Pharmaceutical Industry:
4-CYANO-4-(4-FLUOROPHENYL)CYCLOHEXANONE is used as a reagent for the synthesis of novel 4,4-disubstituted cyclohexylbenzamide derivatives. These derivatives have been identified as potent 11β-HSD1 inhibitors, which are important targets for the treatment of various metabolic disorders, such as type 2 diabetes and obesity. 4-CYANO-4-(4-FLUOROPHENYL)CYCLOHEXANONE's unique structure allows for the development of new drugs with improved efficacy and selectivity.

InChI:InChI=1/C13H12FNO/c14-11-3-1-10(2-4-11)13(9-15)7-5-12(16)6-8-13/h1-4H,5-8H2

Upstream product

• 56326-95-5 methyl 5-cyano-5-(4-fluorophenyl)-2-oxocyclohexanecarboxylate 
• 459-22-3 4-fluorophenylacetonitrile 
• 95-47-6 o-xylene 
• 292638-85-8 acrylic acid methyl ester 
• 554-12-1 propanoic acid methyl ester 

Downstream Products

• 100240-30-0 1-(4-fluorophenyl)-4-[4-(3-pyridazinyl)-1-piperazinyl]-3-cyclohexenecarbonitrile 
• 56327-00-5 8-(4-fluoro-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 1202006-99-2 (1s,4s)-1-(4-fluorophenyl)-4-hydroxycyclohexanecarbonitrile 
• 1202176-63-3 cis-2-methyl-propane-2-sulfinic acid {2-benzenesulfonyl-1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide 
• 1202007-07-5 trans-4-(1-amino-butyl)-4-(4-fluoro-phenyl)-cyclohexanol hydrochloride 
• 1202007-12-2 cis-1-[4-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-propylamine 
• 1202008-66-9 cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide 
• 1202008-72-7 C₂₁H₃₂FNO₄S 
• 1202008-71-6 2-methyl-propane-2-sulfinic acid {1-[8-(4-fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-3-methoxy-propyl}-amide 
• 1202007-03-1 {1-[8-(4-fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-butyl}-carbamic acid tert-butyl ester 
• 1202008-65-8 cis-2-methyl-propane-2-sulfinic acid 1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-methylideneamide 
• 1202008-51-2 C₂₀H₃₃FO₄SSi 
• 1202007-05-3 trans-{1-[1-(4-fluoro-phenyl)-4-hydroxy-cyclohexyl]-butyl}-carbamic acid tert-butyl ester 
• 1202008-70-5 2-methyl-propane-2-sulfinic acid {1-[8-(4-fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-allyl}-amide 

Relevant academic research and scientific papers

Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors

The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-human primate ex vivo pharmacodynamic models.

SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES

The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

DI(HETERO)ARYLCYCLOHEXANE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The present invention relates to di(hetero)arylcyclohexane derivatives of the formula (I), in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula (I), their use and pharmaceutical compositions comprising them.

Potent bradykinin B1 receptor antagonists: 4-Substituted phenyl cyclohexanes

Selective bradykinin (BK) B1 receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B1 receptor antagonists.

Benzamide derivatives and uses related thereto

Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.

An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane β-keto esters

(Chemical Equation Presented) A simple, scalable, and efficient one-pot methodology for the synthesis of 4,4-disubstituted cyclohexane β-keto esters from benzylic nitriles or esters and methyl acrylate promoted by potassium tert-butoxide is described. The process relies on a tandem double Michael addition-Dieckmann condensation reaction, which results in the formation of three discrete carbon-carbon bonds in a single pot, including a quaternary center. The method allows for the convenient and rapid synthesis of a variety of 4-aryl-4-cyano-2-carbomethoxycyclohexanone and 4-aryl-2,4- biscarbomethoxycyclohexanone building blocks for use in natural products synthesis and medicinal chemistry.

Anti-virally active pyridazinamines

Anti-virally active pyridazinamines, compositions containing the same and methods of treating viral diseases in warm-blooded animals.

1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Novel 1-(cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives, bearing in the 4-position of the cyclohexyl ring a cyano group and an aryl moiety, said compounds displaying useful antihistaminic properties.