5634-53-7

Basic information

• Product Name: 2-(Hydroxyimino)propanoic acid methyl ester
• Synonyms: 2-(Hydroxyimino)propanoic acid methyl ester;2-(Hydroxyimino)propionic acid methyl ester
• CAS NO: 5634-53-7
• Molecular Formula: C₄H₇NO₃
• Molecular Weight: 117.1
• Mol File: 5634-53-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 463.1°C at 760 mmHg
• Flash Point: 233.9°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 9.31E-09mmHg at 25°C
• Refractive Index: 1.753
• CAS DataBase Reference: 2-(Hydroxyimino)propanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Hydroxyimino)propanoic acid methyl ester(5634-53-7)
• EPA Substance Registry System: 2-(Hydroxyimino)propanoic acid methyl ester(5634-53-7)

Safety Data

• Hazardous Substances Data: 5634-53-7(Hazardous Substances Data)

Usage

Type of compound

derivative of propanoic acid

Industries used

pharmaceutical and chemical

Physical form

colorless solid

Melting point

54-58°C

Boiling point

146-148°C

Use as a reagent

in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals

Potential applications

treatment of neurodegenerative diseases, chemoattractant for neutrophils

Range of uses and applications

various fields

InChI:InChI=1/C15H11NOS3/c1-10-5-2-3-7-12(10)16-14(17)13(20-15(16)18)9-11-6-4-8-19-11/h2-9H,1H3/b13-9+

Upstream product

• 17094-21-2 2-methyl-acetoacetic acid methyl ester 
• 67-56-1 methanol 
• 2211-14-5 2-hydroxyiminopropanoic acid 
• 27871-49-4 (S)-Methyl lactate 
• 1028432-16-7 C₁₇H₂₉NO₅SSi 
• 600-22-6 pyruvic acid methyl ester 
• 34880-70-1 [1-methoxyprop-1-enyloxy]trimethylsilane 
• 5445-17-0 Methyl 2-bromopropionate 

Downstream Products

• 353796-63-1 methyl 2-(O-benzyloxyimino)-propanoate 
• 600-22-6 pyruvic acid methyl ester 
• 7625-53-8 rac-Ala-OMe 

Relevant articles and documents

Kinetics and mechanism for oxime formation from methyl pyruvate

Rate and equilibrium constants for methyl pyruvate oxime formation were determined as a function of pH over the range 0-7 in aqueous solution at 30°C and ionic strength 0.5 by spectrophotometric methods. The reaction occurs with rate-determining carbinolamine dehydration over the entire range of pH investigated. Carbinolamine dehydration is not susceptible to detectable general acid-base catalysis by a carboxylic acid buffer or hydroxylamine/hydroxylammonium ion buffer. Specific acid catalysis for carbinolamine formation is dominant at pH values below 5. Above that value, a pH-independent, water-catalyzed reaction becomes apparent. The pH-independent carbinolamine dehydration is unusually important with this substrate. Copyright

Efficient synthesis of oxime using o-tbs-n-tosylhydroxylamine: Preparation of (2z)-4-(benzyloxy)but-2-enal oxime

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Microwave-promoted one-pot conversion of alcohols to oximes using 1-methylimidazolium nitrate, [Hmim][NO3], as a green promoter and medium

A wide variety of oximes were prepared from different types of alcohols with hydroxylamine hydrochloride using 1-methylimidaziloum nitrate, [Hmim][NO3], ionic liquid as a reaction medium and promoter under microwave irradiation. This protocol provides a one-pot oxime synthesis with high yields that is facile, eco-friendly and the ionic liquid can be recovered and reused.