56355-48-7

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 127414-08-8 ethyl 2-cyano-2-(3-fluoro-4-methoxyphenyl)propionate 
• 127437-35-8 Cyano-(3-fluoro-4-methoxy-phenyl)-acetic acid ethyl ester 
• 404-90-0 2-(3-fluoro-4-methoxyphenyl)acetonitrile 
• 351-52-0 3-fluoro-4-methoxybenzyl chloride 
• 79281-00-8 2-(3-fluoro-4-methoxyphenyl)propanoic acid 

Downstream Products

• 127414-07-7 2-[4-(4-Chloro-benzyloxy)-3-fluoro-phenyl]-propionic acid 
• 127437-34-7 2-(3-fluoro-4-benzyloxyphenyl)propanoic acid 
• 79280-93-6 methyl 2-(3-fluoro-4-hydroxyphenyl)propionate 

Relevant academic research and scientific papers

USE OF QSAR IN DESIGN OF ANTIINFLAMMATORY FLUORINATED ARYLALKANOIC ACIDS

A series of 3-fluoro-4-alkoxyphenylalkanoic acids III was synthetized and their antiinflammatory activity and fibrinolytic capacity was evaluated.The suitable fluorinated derivative with better pharmacological profile than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) was selected.Experimental, biological activities of acids III were compared with those calculated by introducing the physico-chemical parameters into the formerly derived regression equations.Good coincidence was found out, as well as similarity of the regression equations derived for the originalseries of acids extended by the acids III.Lipophilicity of the acids under study was evaluated by partition thin-layer chromatography; the values of log P of benzyloxy derivatives IIIc-IIIf were lower than tabulated values - probably due to the intramolecular hydrophobic interactions of aromatic nuclei.