5636-68-0Relevant academic research and scientific papers
General approach for the synthesis of polyquinanes. Facile generation of molecular complexity via reaction of 1,2-dicarbonyl compounds with dimethyl 3-ketoglutarate
Mitschka,Oehldrich,Takahashi,Cook,Weiss,Silverton
, p. 4521 - 4542 (1981)
The condensation of dimethyl 3-ketoglutarate 1 with 1,2-dicarbonyl compounds provides access to the polyquinane derivatives tricyclo[6.3.0.01,5]undecane - 3,7,9 - trione 27, tricyclo[3.3.3.01,5]undecane 31; tetra-cyclo[5.5.1.04,
New pyridazine derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents; design, synthesis and biological evaluation
Ahmed, Eman M.,Hassan, Marwa S.A.,El-Malah, Afaf A.,Kassab, Asmaa E.
, (2020)
New pyridazinone and pyridazinthione derivatives were designed, synthesized and identified through performing 1H NMR, 13C NMR, IR and MS spectroscopic techniques. All the newly synthesized derivatives were evaluated for cyclooxygenas
Synthesis and anti-inflammatory activity of novel pyridazine and pyridazinone derivatives as non-ulcerogenic agents
Saeed, Makarem M.,Khalil, Nadia A.,Ahmed, Eman M.,Eissa, Kholoud I.
, p. 2077 - 2092 (2013/08/25)
Herein, we report the synthesis and pharmacological properties of several series of pyridazine and pyridazinone derivatives. All the synthesized compounds were tested, in vivo, for their anti-inflammatory and ulcerogenic properties against indomethacin, a
Structure-based molecular design, synthesis, and in vivo anti-inflammatory activity of pyridazinone derivatives as nonclassic COX-2 inhibitors
Abouzid, Khaled A. M.,Khalil, Nadia A.,Ahmed, Eman M.,El-Latif, Hekmat A. Abd,El-Araby, Moustafa E.
scheme or table, p. 629 - 642 (2011/12/02)
A scaffold with bicyclic core carrying pyridazinone moiety, which exhibited potent in vivo anti-inflammatory activities, was introduced in this article. The design of these compounds was assisted by docking and superposition experiments on cyclooxygenase-
General approach for the synthesis of polyquinanes. Facile generation of molecular complexity via reaction of 1,2-dicarbonyl compounds with dimethyl 3-ketoglutarate
Mitschka,Oehldrich,Takahashi,Cook,Weiss,Silverton
, p. 4521 - 4542 (2014/12/10)
The condensation of dimethyl 3-ketoglutarate 1 with 1,2-dicarbonyl compounds provides access to the polyquinane derivatives tricyclo[6.3.0.01,S]undecane-3,7,9-trione 27, tricyclo[3.3.3.01,s]undecane 31; tetra-cyclo[5.5.1.04,13.010,13]-tridecane-2,6,8,12-tetraone 41; tetracycloI6.6.0.0u.0,l3ltetradecane-2,7,9,14-tetraone 44; and the tetracyclo(5.5.1.01013]tridecane triones Sb and 6b. The unique structure of staurane tetraone 41 has resulted in spontaneous resolution of the two antipodes on crystallization from DMF. In addition, examination of the crystal structures of tetraones 41 and 44, in terms of strain energy, coupled with the steric accessibility of the /5-diketone functionality contained in 41 and 44 have been employed to explain why tetraone 44 and trione 27 undergo a retro-Claisen reaction (CH3OH) more rapidly than staurane tetraone 41.
