56377-45-8

Basic information

• Product Name: S-tert-butyl chloroethanethioate
• Synonyms: ethanethioic acid, 2-chloro-, S-(1,1-dimethylethyl) ester; ethanethioic acid, chloro-, S-(1,1-dimethylethyl) ester; S-(tert-butyl) chloroethanethioate; S-tert-Butyl chloroethanethioate
• CAS NO: 56377-45-8
• Molecular Formula: C₆H₁₁ClOS
• Molecular Weight: 166.6689
• Mol File: 56377-45-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 190.3°C at 760 mmHg
• Flash Point: 68.9°C
• Density: 1.11g/cm³
• Vapor Pressure: 0.544mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: S-tert-butyl chloroethanethioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-tert-butyl chloroethanethioate(56377-45-8)
• EPA Substance Registry System: S-tert-butyl chloroethanethioate(56377-45-8)

Safety Data

• Hazardous Substances Data: 56377-45-8(Hazardous Substances Data)

Upstream product

• 75-66-1 2-methylpropan-2-thiol 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 163881-60-5 (2S,3S)-2-Chloro-3-hydroxy-3-phenyl-thiopropionic acid S-tert-butyl ester 
• 112303-67-0 S-tert-butyl (3R)-3-hydroxy-3-phenylpropanethioate 

Relevant articles and documents

Highly enantio- and diastereoselective boron aldol reactions of α-heterosubstituted thioacetates with aldehydes and silyl imines

Boron enolates derived from α-heterosubstituted thioacetates and bearing menthone-derived chiral ligands react with aldehydes to give anti aldols with excellent diastero- and enantiocontrol. Boron enolates derived from tert-butyl α-halothioacetate and bearing menthone-derived chiral ligands react with imines with excellent diastero- and enantiocontrol to give syn α-halo-β-aminothioesters, which can be converted to the corresponding aziridines by simple ring closure during LAH reduction. A key precursor of antibiotics (+)-thiamphenicol and (-)-florfenicol was synthesized.